Author

C. A. Parent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

P. A. Coulombe· 3 shared Y. Xu· 3 shared S. SenGupta· 2 shared A. G. Zieman· 1 shared A. V. Smrcka· 1 shared C. Johnson· 1 shared C. N. Johnson· 1 shared D. B. Lombard· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersImmunology

P. A. Coulombe

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Author profile →

5 papers

Recent·Most cited

Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation

S. B. Arya, S. P. Collie, Y. Xu, M. Fernandez, J. Z. Sexton, S. Mosalaganti, P. A. Coulombe, C. A. Parent

This study shows neutrophils release nuclear DNA via exosomes to resolve sterile inflammation, with implications for treating inflammatory diseases.

bioRxiv · Apr 21, 2024Immunology

Keratin 17- and PKCα-dependent transient amplification of neutrophil influx after repeated stress to the skin

Y. Xu, E. Cohen, C. N. Johnson, C. A. Parent, P. A. Coulombe

The paper identifies a keratin 17- and PKCα-dependent mechanism that transiently amplifies neutrophil influx in stressed skin, revealing a novel pathway in chronic inflammatory skin diseases.

bioRxiv · Oct 11, 2023Immunology

Identification of G Protein αi Signaling Partners by Proximity Labeling Reveals a Network of Interactions that Includes PDZ-RhoGEF

N. R. Chandan, S. Abraham, S. SenGupta, C. A. Parent, A. V. Smrcka

The paper identifies G protein αi signaling partners using proximity labeling, revealing a network including PDZ-RhoGEF and functional differences among Gi isoforms.

bioRxiv · Jul 15, 2021Pharmacology & Toxicology

TRIPLE-NEGATIVE BREAST CANCER CELLS RECRUIT NEUTROPHILS BY SECRETING TGF-β AND CXCR2 LIGANDS

S. SENGUPTA, L. E. Hein, Y. Xu, J. Zhang, J. Konwerski, Y. Li, C. Johnson, D. Cai, J. Smith, C. A. Parent

This study identifies that TNBC cells recruit neutrophils by secreting TGF-β and CXCR2 ligands, promoting tumor progression.

bioRxiv · Jan 28, 2021Immunology

A role for keratins in supporting mitochondrial organization and function in skin keratinocytes

K. Steen, D. Chen, F. Wang, S. Chen, S. Kumar, D. B. Lombard, R. Weigert, A. G. Zieman, C. A. Parent, P. A. Coulombe

This study shows that keratins K6 and K16 regulate mitochondrial structure, function, and dynamics in keratinocytes, contributing to oxidative stress in pachyonychia congenita.

bioRxiv · Mar 10, 2020Cell Biology