R. Schiffelers

mRNA-LNP COVID-19 vaccine lipids induce low level complement activation and production of proinflammatory cytokines: Mechanisms, effects of complement inhibitors, and relevance to adverse reactions

This study investigates how mRNA-LNP vaccines trigger complement activation and cytokine production, linking these processes to inflammatory adverse events and suggesting potential therapeutic strategies.

The fluid membrane determines mechanics of red blood cell extracellular vesicles and is softened in hereditary spherocytosis

This study uses atomic force microscopy to analyze the mechanical properties of red blood cell extracellular vesicles from healthy individuals and a hereditary spherocytosis patient, finding that vesicles have a lower bending modulus in the disease state.