L. Claesson-Welsh

Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions

This study shows that Neuropilin-1 (NRP1) on perivascular cells modulates VEGFA/VEGFR2 signaling in endothelial cells, affecting vascular permeability in a tissue-specific manner.

A critical role of VEGFR2 in lymphatic tumor metastasis

This study shows that VEGFR2 in lymphatic endothelial cells promotes tumor metastasis by regulating lymphatic valve formation and tumor-associated lymphangiogenesis.

Claudin5 protects the peripheral endothelial barrier in an organ and vessel type-specific manner

The paper identifies Claudin5's organ- and vessel-type-specific role in maintaining endothelial barrier integrity through single-cell RNAseq analysis and functional studies in mice.

p73 is required for vessel integrity controlling endothelial junctional dynamics through Angiomotin

This study identifies p73 as a regulator of endothelial junction dynamics through Angiomotin, showing its role in maintaining vessel integrity and preventing hyperpermeability.

Endothelial Unc5B controls blood-brain barrier integrity

This study shows that endothelial Unc5B maintains blood-brain barrier integrity via Wnt/{beta}-catenin signaling, with potential therapeutic applications for CNS diseases.

eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

The paper investigates eNOS's role in retinopathy by showing it disrupts vascular barriers via c-Src and VE-cadherin phosphorylation, and demonstrates that inhibiting NO formation reduces leakage.

Pre-determined macromolecular leakage sites with dynamic properties establish endothelial intra-vessel heterogeneity

The paper identifies pre-determined leakage sites in endothelial cells that show dynamic properties and contribute to intra-vessel heterogeneity, impacting barrier stability and drug delivery.

Paladin is a PI(4,5)P2 phosphoinositide phosphatase that regulates endosomal signaling and angiogenesis