Author

P. Bhat-Nakshatri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. M. Storniolo· 4 shared H. Nakshatri· 4 shared G. Sandusky· 3 shared H. Gao· 3 shared P. C. McGuire· 3 shared Y. Liu· 3 shared A. S. Khatpe· 2 shared D. Chen· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCancer Biology

A. M. Storniolo

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4 papers

Recent·Most cited

Single nuclei chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry

P. Bhat-Nakshatri, H. Gao, A. S. Khatpe, P. C. McGuire, C. Erdogan, D. Chen, G. Jiang, F. New, R. German, A. M. Storniolo, Y. Liu, H. Nakshatri

The paper develops a chromatin accessibility and gene expression atlas of human breast tissues from 92 donors of diverse genetic ancestry, identifying 10 cell types and ancestry-dependent gene expression patterns.

bioRxiv · Oct 4, 2023 · PreprintCancer Biology

Influence of genetic ancestry on breast stromal cells provides biologic basis for increased incidence of metaplastic breast cancer in women of African descent

B. Kumar, K. Batic, P. Bhat-Nakshatri, M. M. Granatir, R. J. Addison, M. Szymanski, L. A. Baldridge, C. J. Temm, G. Sandusky, S. K. Althouse, A. M. Storniolo, H. Nakshatri

The paper identifies PZP stromal cells enriched in African Ancestry women that may contribute to metaplastic breast cancer incidence through epithelial communication and STAT3 activation.

Nature Communications · Sep 14, 2023Peer-reviewedCancer Biology

BRCA1 and BRCA2 germline mutations driven signaling pathway alterations are sufficient to initiate breast tumorigenesis by the PIK3CAH1047R oncogene.

P. Bhat-Nakshatri, A. S. Khatpe, D. Chen, K. Batic, H. Mang, C. Herodotou, P. C. McGuire, X. Xuei, H. Gao, Y. Liu, G. Sandusky, A. M. Storniolo, H. Nakshatri

This paper compares single-cell transcriptomes of BRCA1/2 mutation carriers and non-carriers to show how these mutations alter signaling pathways and drive breast cancer development through PIK3CA mutations.

bioRxiv · Jul 26, 2023 · PreprintCancer Biology

A single cell atlas of the healthy breast tissues reveal clinically relevant clusters of breast epithelial cells

P. Bhat-Nakshatri, H. Gao, P. C. McGuire, X. Xuei, S. Liu, J. Wan, Y. Liu, S. K. Althouse, A. Colter, G. Sandusky, A. M. Storniolo, H. Nakshatri

The paper identifies 13 breast epithelial cell clusters in healthy breast tissues and links some clusters to breast cancer origins and prognosis.

bioRxiv · Jun 25, 2020Cancer Biology