Author

X. Xuei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Organism:human· 5 Research Focus:differential expression· 4 Organism:mouse· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

H. Gao· 6 shared Y. Liu· 4 shared S. Liu· 3 shared A. M. Storniolo· 2 shared D. Chen· 2 shared G. Cottone· 2 shared G. Sandusky· 2 shared H. Nakshatri· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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6 shared papersCancer Biology

H. Gao

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Metabolic shift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cells

M. B. Eduardo, G. Cottone, C. W. McCloskey, S. Liu, M. P. Zappia, E. V. Benevolenskaya, A. B. M. M. K. Islam, M. V. Frolov, F. R. Palma, P. Gao, J. Setya, H. Gao, X. Xuei, R. Khokha, J. Locasale, , S. E. Clare

The paper shows that lipid metabolism, specifically through OA, shifts metabolic pathways in breast cells, increasing SAM and 2-HG, which contribute to oncogenic properties and epigenetic changes.

bioRxiv · Feb 21, 2024 · PreprintCancer Biology

BRCA1 and BRCA2 germline mutations driven signaling pathway alterations are sufficient to initiate breast tumorigenesis by the PIK3CAH1047R oncogene.

P. Bhat-Nakshatri, A. S. Khatpe, D. Chen, K. Batic, H. Mang, C. Herodotou, P. C. McGuire, X. Xuei, H. Gao, Y. Liu, G. Sandusky, A. M. Storniolo, H. Nakshatri

This paper compares single-cell transcriptomes of BRCA1/2 mutation carriers and non-carriers to show how these mutations alter signaling pathways and drive breast cancer development through PIK3CA mutations.

bioRxiv · Jul 26, 2023 · PreprintCancer Biology

Origin, Prospective Identification, and Function of Circulating Endothelial Colony Forming Cells in Mouse and Human

Y. Lin, K. Banno, C.-H. Gil, J. Myslinski, T. Hato, W. C. Shelley, H. Gao, X. Xuei, Y. Liu, D. P. Basile, M. Yoshimoto, N. Prasain, S. P. Tarnawsky, R. H. Adams, K. Naruse, , M. C. Yoder

This study identifies the origin and function of circulating endothelial colony forming cells (C-ECFCs) in mice and humans, showing they arise from tissue-resident ECFCs and have vasculogenic potential.

bioRxiv · Jul 31, 2022 · PreprintCell Biology

Single Cell Cortical Bone Transcriptomics Defines Novel Osteolineage Gene Sets Altered in Chronic Kidney Disease

R. Agoro, I. Nookaew, M. Noonan, Y. G. Marambio, S. Liu, W. Chang, H. Gao, L. M. Hibbard, C. E. Metzger, D. Horan, W. R. Thompson, X. Xuei, Y. Liu, C. Zhang, A. G. Robling, , K. E. White

The paper defines novel osteolineage gene sets using single-cell transcriptomics and identifies molecular defects in a CKD mouse model.

bioRxiv · Jul 30, 2022Cell Biology

Translation rescue by targeting Ppp1r15a upstream open reading frame in vivo

A. Kidwell, S. P. S. Yadav, B. Maier, A. Zollman, K. Ni, A. Halim, D. Janosevic, J. Myslinski, F. Syed, L. Zeng, A. Bopda Waffo, K. Banno, X. Xuei, E. H. Doud, P. C. Dagher, T. Hato

This study shows that targeting the Ppp1r15a upstream open reading frame rescues translation and improves kidney function in sepsis by overcoming uORF-mediated repression.

bioRxiv · Dec 11, 2021Physiology

Exposure of mammary cells to lipid activates gene expression changes associated with ER-negative breast cancer via chromatin remodeling.

S. Yadav, R. Virk, C. Chung, D. Van Derway, D. Chen, K. Burdett, H. Gao, Z. Zeng, M. Ranjan, G. Cottone, X. Xuei, S. Chandrasekaran, V. Backman, R. Chaterton, S. Khan, S. Clare

The paper shows lipid exposure alters gene expression and chromatin features in mammary cells, linking these changes to ER-negative breast cancer development.

bioRxiv · Dec 13, 2020 · PreprintCancer Biology

A single cell atlas of the healthy breast tissues reveal clinically relevant clusters of breast epithelial cells

P. Bhat-Nakshatri, H. Gao, P. C. McGuire, X. Xuei, S. Liu, J. Wan, Y. Liu, S. K. Althouse, A. Colter, G. Sandusky, A. M. Storniolo, H. Nakshatri

The paper identifies 13 breast epithelial cell clusters in healthy breast tissues and links some clusters to breast cancer origins and prognosis.

bioRxiv · Jun 25, 2020Cancer Biology