Author

H. Nakshatri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 8 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:cell type annotation· 5 Research Focus:differential expression· 5 Assay:bulk RNA-seq· 4 Research Focus:cancer & tumor microenvironment· 4 Research Focus:gene regulatory network inference· 4 Assay:scRNA-seq· 4

Frequent Co-Authors

A. M. Storniolo· 5 shared P. Bhat-Nakshatri· 4 shared G. Sandusky· 3 shared H. Gao· 3 shared P. C. McGuire· 3 shared S. K. Althouse· 3 shared Y. Liu· 3 shared A. S. Khatpe· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersCancer Biology

A. M. Storniolo

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Author profile →

9 papers

Recent·Most cited

Single nuclei chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry

P. Bhat-Nakshatri, H. Gao, A. S. Khatpe, P. C. McGuire, C. Erdogan, D. Chen, G. Jiang, F. New, R. German, A. M. Storniolo, Y. Liu, H. Nakshatri

The paper develops a chromatin accessibility and gene expression atlas of human breast tissues from 92 donors of diverse genetic ancestry, identifying 10 cell types and ancestry-dependent gene expression patterns.

bioRxiv · Oct 4, 2023 · PreprintCancer Biology

Influence of genetic ancestry on breast stromal cells provides biologic basis for increased incidence of metaplastic breast cancer in women of African descent

B. Kumar, K. Batic, P. Bhat-Nakshatri, M. M. Granatir, R. J. Addison, M. Szymanski, L. A. Baldridge, C. J. Temm, G. Sandusky, S. K. Althouse, A. M. Storniolo, H. Nakshatri

The paper identifies PZP stromal cells enriched in African Ancestry women that may contribute to metaplastic breast cancer incidence through epithelial communication and STAT3 activation.

Nature Communications · Sep 14, 2023Peer-reviewedCancer Biology

Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversion

R. Kudo, A. Safonov, E. M. da Silva, Q. Li, H. Shao, M. Will, A. Fushimi, H. Nakshatri, J. S. Reis-Filho, S. Goel, A. Koff, B. Weigelt, Q. J. Khan, P. Razavi, S. Chandarlapaty

The paper identifies TP53 loss and MDM2 amplification as factors associated with poor long-term response to CDK4/6 inhibition in breast cancer and shows that CDK2 inhibition can overcome this resistance.

bioRxiv · Aug 25, 2023Cancer Biology

BRCA1 and BRCA2 germline mutations driven signaling pathway alterations are sufficient to initiate breast tumorigenesis by the PIK3CAH1047R oncogene.

P. Bhat-Nakshatri, A. S. Khatpe, D. Chen, K. Batic, H. Mang, C. Herodotou, P. C. McGuire, X. Xuei, H. Gao, Y. Liu, G. Sandusky, A. M. Storniolo, H. Nakshatri

This paper compares single-cell transcriptomes of BRCA1/2 mutation carriers and non-carriers to show how these mutations alter signaling pathways and drive breast cancer development through PIK3CA mutations.

bioRxiv · Jul 26, 2023 · PreprintCancer Biology

Aberrant epigenetic and transcriptional events associated with breast cancer risk

N. Marino, R. German, R. Podicheti, D. B. Rusch, P. Rockey, J. Huang, G. E. Sandusky, C. J. Temm, S. K. Althouse, K. P. Nephew, H. Nakshatri, J. Liu, A. Vode, S. Cao, A. M. Storniolo

This study identifies molecular aberrations in normal breast tissue from high-risk women, linking epigenetic and transcriptional changes to breast cancer susceptibility.

bioRxiv · Sep 14, 2021Cancer Biology

Building a virtual summer research experience in cancer for high school and early undergraduate students: lessons from the COVID-19 pandemic

T. W. Corson, S. M. Hawkins, E. Sanders, J. Byram, L.-A. Cruz, J. Olson, E. Speidell, R. Schnabel, A. Balaji, O. Ogbeide, J. Dinh, A. Hinshaw, L. Cummings, V. Bonds, H. Nakshatri

This paper describes a virtual summer research program in cancer for high school and early undergraduate students during the COVID-19 pandemic and evaluates its outcomes.

bioRxiv · Nov 23, 2020Scientific Communication & Education

Aged Breast Extracellular Matrix Drives Mammary Epithelial Cells to an Invasive and Cancer-Like Phenotype

G. Bahcecioglu, X. Yue, E. Howe, I. Guldner, M. S. Stack, H. Nakshatri, S. Zhang, P. Zorlutuna

This study shows that aged breast ECM drives mammary epithelial cells to an invasive, cancer-like phenotype through mechanisms involving EMT and LOX.

bioRxiv · Sep 30, 2020Cancer Biology

Deubiquitinase UCHL1 Maintains Protein Homeostasis through PSMA7-APEH-Proteasome Axis in High-Grade Serous Ovarian Carcinoma

A. Tangri, K. Lighty, J. Loganathan, F. Mesmar, R. Podicheti, C. Zhang, M. Iwanicki, H. Nakshatri, S. Mitra

This study identifies UCHL1's role in maintaining protein homeostasis in HGSOC via the PSMA7-APEH-proteasome axis, showing its importance for tumor growth and suggesting therapeutic targeting.

bioRxiv · Sep 28, 2020Cancer Biology

A single cell atlas of the healthy breast tissues reveal clinically relevant clusters of breast epithelial cells

P. Bhat-Nakshatri, H. Gao, P. C. McGuire, X. Xuei, S. Liu, J. Wan, Y. Liu, S. K. Althouse, A. Colter, G. Sandusky, A. M. Storniolo, H. Nakshatri

The paper identifies 13 breast epithelial cell clusters in healthy breast tissues and links some clusters to breast cancer origins and prognosis.

bioRxiv · Jun 25, 2020Cancer Biology