A. M. Storniolo

Single nuclei chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry

The paper develops a chromatin accessibility and gene expression atlas of human breast tissues from 92 donors of diverse genetic ancestry, identifying 10 cell types and ancestry-dependent gene expression patterns.

Influence of genetic ancestry on breast stromal cells provides biologic basis for increased incidence of metaplastic breast cancer in women of African descent

The paper identifies PZP stromal cells enriched in African Ancestry women that may contribute to metaplastic breast cancer incidence through epithelial communication and STAT3 activation.

BRCA1 and BRCA2 germline mutations driven signaling pathway alterations are sufficient to initiate breast tumorigenesis by the PIK3CAH1047R oncogene.

This paper compares single-cell transcriptomes of BRCA1/2 mutation carriers and non-carriers to show how these mutations alter signaling pathways and drive breast cancer development through PIK3CA mutations.

Aberrant epigenetic and transcriptional events associated with breast cancer risk

This study identifies molecular aberrations in normal breast tissue from high-risk women, linking epigenetic and transcriptional changes to breast cancer susceptibility.

DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

A single cell atlas of the healthy breast tissues reveal clinically relevant clusters of breast epithelial cells

The paper identifies 13 breast epithelial cell clusters in healthy breast tissues and links some clusters to breast cancer origins and prognosis.