Author

P. Brzezinski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:cryo-EM· 4 Research Focus:protein structure prediction· 3 Organism:C. elegans· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

J. L. Rubinstein· 6 shared A. Moe· 3 shared J. Di Trani· 3 shared D. J. Yanofsky· 2 shared S. A. Bueler· 2 shared S. Krol· 2 shared A. Plourde· 1 shared D. Riepl· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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6 shared papersBiochemistry

J. L. Rubinstein

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6 papers

Recent·Most cited

Structure of mycobacterial respiratory Complex I

Y. Liang, A. Plourde, S. A. Bueler, J. Liu, P. Brzezinski, S. Vahidi, J. L. Rubinstein

The paper determines the structure of mycobacterial Complex I using cryoEM, revealing its composition and interactions with menaquinone and a unique lipid.

bioRxiv · Oct 4, 2022Biochemistry

Structural basis of mammalian Complex IV inhibition by steroids

J. Di Trani, A. Moe, D. Riepl, P. Saura, V. R. I. Kaila, P. Brzezinski, J. L. Rubinstein

This study identifies a steroid-binding site on Complex IV and shows how steroid binding inhibits proton uptake through the K-pathway.

bioRxiv · Apr 13, 2022Biophysics

Structure of mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203)

D. J. Yanofsky, J. M. Di Trani, S. Krol, R. Abdelaziz, S. A. Bueler, P. Imming, P. Brzezinski, J. L. Rubinstein

This study determines the structure of the mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug telacebec, revealing its mechanism of inhibiting menaquinol oxidation.

bioRxiv · Jul 6, 2021Biochemistry

The respiratory supercomplex from C. glutamicum

A. Moe, T. Kovalova, S. Krol, D. J. Yanofsky, M. Bott, D. Sjöstrand, J. L. Rubinstein, M. Högbom, P. Brzezinski

This paper determines the structure of the CIII2CIV2 supercomplex from C. glutamicum using cryo-EM, revealing its architecture and proton transport pathway.

bioRxiv · Jun 16, 2021Biochemistry

Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III

J. Di Trani, Z. Liu, L. Whitesell, P. Brzezinski, L. Cowen, J. L. Rubinstein

This study uses cryoEM to analyze the structure and dynamics of the Rieske head domain in Candida albicans Complex III and shows how Inz-5 alters its conformational equilibrium.

bioRxiv · May 18, 2021Biochemistry

Cryo-EM structure and kinetics reveal electron transfer by 2D diffusion of cytochrome c in the yeast III-IV respiratory supercomplex

A. Moe, J. Di Trani, J. L. Rubinstein, P. Brzezinski

This paper uses cryo-EM and kinetic studies to show that cytochrome c transfers electrons via 2D diffusion along the surface of yeast III2IV1/2 supercomplexes, enhancing electron transfer efficiency.

bioRxiv · Nov 27, 2020Biochemistry