Author

S. A. Bueler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:cryo-EM· 6 Research Focus:protein structure prediction· 5 Research Focus:cell type annotation· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein folding & dynamics· 2 Organism:rat· 2 Organism:yeast· 2

Frequent Co-Authors

J. L. Rubinstein· 8 shared G. M. Courbon· 2 shared J. Liu· 2 shared J. M. Di Trani· 2 shared P. Brzezinski· 2 shared Y. Liang· 2 shared A. Plourde· 1 shared A.-C. Gingras· 1 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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8 shared papersBiochemistry

J. L. Rubinstein

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Author profile →

8 papers

Recent·Most cited

High resolution cryo-EM of V-ATPase in native synaptic vesicles

C. E. Coupland, R. Karimi, S. A. Bueler, Y. Liang, G. M. Courbon, J. M. Di Trani, C. J. Wong, R. Saghian, J.-Y. Youn, L.-Y. Wang, J. L. Rubinstein

The paper determines the high-resolution structure of V-ATPase in native synaptic vesicles using cryo-EM, revealing interactions with cholesterol and synaptophysin.

bioRxiv · Apr 1, 2024Biochemistry

Structural basis of V-ATPase VO region assembly by Vma12p, 21p, and 22p

H. Wang, S. A. Bueler, J. L. Rubinstein

This study reveals how Vma12p, Vma21p, and Vma22p assemble and regulate V-ATPase VO region to prevent premature V1 binding and ensure proper acidification of cellular compartments.

bioRxiv · Oct 19, 2022Biochemistry

Structure of mycobacterial respiratory Complex I

Y. Liang, A. Plourde, S. A. Bueler, J. Liu, P. Brzezinski, S. Vahidi, J. L. Rubinstein

The paper determines the structure of mycobacterial Complex I using cryoEM, revealing its composition and interactions with menaquinone and a unique lipid.

bioRxiv · Oct 4, 2022Biochemistry

Coordinated conformational changes in the V1 complex during V-ATPase reversible dissociation

T. Vasanthakumar, K. A. Keon, S. A. Bueler, M. C. Jaskolka, J. L. Rubinstein

The paper uses cryoEM to study conformational changes in yeast V1 complex during V-ATPase dissociation, revealing how subunit C enables reassembly with VO.

bioRxiv · Nov 9, 2021Biochemistry

CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7

Y. Z. Tan, Y. M. Abbas, J. Z. Wu, D. Wu, G. G. Hesketh, S. A. Bueler, A.-C. Gingras, C. V. Robinson, S. Grinstein, J. L. Rubinstein

The paper uses cryoEM to study endogenous V-ATPase interactions with mEAK-7 in porcine kidney, revealing structural insights and functional differences compared to yeast.

bioRxiv · Nov 3, 2021Biochemistry

Structure of mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203)

D. J. Yanofsky, J. M. Di Trani, S. Krol, R. Abdelaziz, S. A. Bueler, P. Imming, P. Brzezinski, J. L. Rubinstein

This study determines the structure of the mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug telacebec, revealing its mechanism of inhibiting menaquinol oxidation.

bioRxiv · Jul 6, 2021Biochemistry

Polymeric assembly of endogenous Tuberous Sclerosis Protein Complex

D. L. Dai, S. M. N. Hasan, G. Woollard, S. A. Bueler, J.-P. Julien, J. L. Rubinstein, M. T. Mazhab-Jafari

The paper demonstrates that endogenous Tuberous Sclerosis Protein Complex (pTSC) assembles into filamentous super-structures in mammalian brains.

bioRxiv · Jan 18, 2021Biochemistry

Structure of mycobacterial ATP synthase with the TB drug bedaquiline

H. Guo, G. M. Courbon, S. A. Bueler, J. Mai, J. Liu, J. L. Rubinstein

This study determines the structure of mycobacterial ATP synthase with and without bedaquiline, revealing how the drug binds and induces conformational changes to inhibit ATP hydrolysis.

bioRxiv · Aug 6, 2020Biochemistry