P. Buchwald

A Composite Biomarker Signature of Type 1 Diabetes Risk Identified via Augmentation of Parallel Multi-Omics Data from a Small Cohort

The paper validates 12 biomarkers from a small T1D cohort using data augmentation, identifying 7 significantly altered markers linked to T1D risk.

Quantitative Receptor Model for Responses That Are Left- or Right-Shifted Versus Occupancy (Are More or Less Concentration Sensitive): The SABRE Approach

The paper introduces the SABRE model to analyze dose-response curves by incorporating signal amplification, showing it can explain both left- and right-shifted responses through changes in signal efficiency.

Quantification of Receptor Binding from Response Data Obtained at Different Receptor Levels: A Simple Individual Sigmoid Fitting and a Unified SABRE Approach

The paper introduces two methods to estimate receptor binding properties from response data without direct binding experiments, using nonlinear regression and a unified SABRE model.

Methylene Blue Is a Nonspecific Protein-Protein Interaction Inhibitor with Potential for Repurposing as an Antiviral for COVID-19

This paper shows methylene blue inhibits SARS-CoV-2 spike-ACE2 interactions and viral replication, with potential as an antiviral for COVID-19.

Small-Molecule In Vitro Inhibitors of the Coronavirus Spike - ACE2 Protein-Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2

The paper identifies small-molecule inhibitors of the SARS-CoV-2 spike-ACE2 interaction, showing they block viral entry with low micromolar activity.

Methylene Blue Inhibits In Vitro the SARS-CoV-2 Spike - ACE2 Protein-Protein Interaction - A Mechanism That Can Contribute to Its Antiviral Activity Against COVID-19

This paper identifies methylene blue as an inhibitor of the SARS-CoV-2 spike-ACE2 interaction, suggesting it may contribute to its antiviral activity against COVID-19.

Cdc42 GTPase Activating Proteins (GAPs) Maintain Generational Inheritance of Cell Polarity and Cell Shape in Fission Yeast

This study shows that Cdc42 GAP proteins Rga4 and Rga6 mediate generational inheritance of cell polarity and shape in fission yeast through asymmetric distribution during cell division.