E. S. Nakayasu

A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis

This paper introduces a fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis, demonstrating its utility in identifying EV proteins related to physical activity.

A Composite Biomarker Signature of Type 1 Diabetes Risk Identified via Augmentation of Parallel Multi-Omics Data from a Small Cohort

The paper validates 12 biomarkers from a small T1D cohort using data augmentation, identifying 7 significantly altered markers linked to T1D risk.

Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice

This study shows that inhibiting PERK reduces autoimmune diabetes risk in mice by decreasing β cell immunogenicity and improving islet function.

Meta-analysis refinement of plasma extracellular vesicle composition identifies proplatelet basic protein as a signaling messenger in type 1 diabetes

Senescent cell-derived extracellular vesicles inhibit cancer recurrence by coordinating immune surveillance

This study shows senescent cell-derived extracellular vesicles (senEVs) suppress tumor growth by coordinating immune surveillance, specifically by recruiting MHC-II+ antigen-presenting cells and activating CCR2+ TH17 cells.

Regulation of translation by lysine acetylation in Escherichia coli

This study shows lysine acetylation in E. coli inhibits translation by disrupting ribosome subunit association, linking metabolic state to protein synthesis.

Legionella pneumophila modulates host energy metabolism by ADP-ribosylation of ADP/ATP translocases

This study identifies Ceg3 as an ADP-ribosyltransferase that modifies host ADP/ATP translocases, impairing their function and modulating host energy metabolism to aid Legionella pneumophila survival.

Comparative molecular and immunoregulatory analysis of extracellular vesicles from Candida albicans and Candida auris.

This study compares extracellular vesicles from Candida auris and Candida albicans, finding distinct molecular profiles and immune-modulating properties that may contribute to C. auris pathogenesis.

Resource reallocation in engineered Escherichia coli strains with reduced genomes

This study examines the effects of genome reduction in E. coli on proteome expression and stability of a biosynthetic pathway for pigment production, finding that proteome fraction elimination impacts fitness and bioproduction balance.

A Histoplasma capsulatum lipid metabolic map identifies antifungal targets

This study constructs a lipid metabolic map of Histoplasma capsulatum and identifies potential antifungal drug targets through pathway validation and compound testing.

Bacterial longevity requires protein synthesis and a stringent response

This study shows that protein synthesis and a stringent response are required for bacterial longevity during growth arrest in Rhodopseudomonas palustris.

Candida auris: multi-omics signature of an emerging and multidrug-resistant pathogen

This paper compares multi-omics profiles of two Candida auris isolates and a Candida albicans reference strain to understand drug resistance and virulence mechanisms.

Listeria monocytogenes virulence factors are secreted in biologically active Extracellular Vesicles

This study shows Listeria monocytogenes secretes biologically active extracellular vesicles containing virulence factors like LLO and PI-PLC, which contribute to cytotoxicity in macrophages.