D. Vavylonis

Myosin-I Synergizes with Arp2/3 Complex to Enhance Pushing Forces of Branched Actin Networks

This study shows myosin-I enhances the force generation of Arp2/3 complex-nucleated actin networks by thinning them and promoting symmetry breaking.

Cdc42 mobility and membrane flows regulate fission yeast cell shape and survival

This study shows that Cdc42 mobility and membrane flows are critical for fission yeast cell shape and survival, with lower mobility leading to impaired polarization and viability.

Design principles of Cdr2 node patterns in fission yeast cells

The paper investigates how Cdr2 nodes form and position in fission yeast cells using experimental and modeling approaches, finding that tip inhibition and cortical anchoring are sufficient for node assembly without a nucleus.

Anillin Related Mid1 as an Adaptive and Multimodal Contractile Ring Anchoring Protein: A Simulation Study

This study simulates Mid1's membrane binding mechanisms, showing multiple binding modes involving its PH and C2 domains, and how these contribute to its role in cytokinetic ring anchoring.

Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast

This study shows that phosphorylation by multiple kinases inhibits Cdc15 phase separation and prevents cytokinetic ring assembly in fission yeast.

Compressive forces stabilise microtubules in living cells

The paper shows that compressive forces stabilize microtubules in living cells through CLASP2 relocation, indicating mechano-responsive properties.

Discrete mechanical model of lamellipodial actin network implements molecular clutch mechanism and generates arcs and microspikes

The paper develops a filament-level model of lamellipodial actin networks to simulate retrograde flow and mechanical behavior, showing how parameters affect stress distribution and protrusion morphology.

A mechanism with severing near barbed ends and annealing explains structure and dynamics of dendritic actin networks

The paper proposes a mechanism involving severing near barbed ends and annealing to explain the structure and dynamics of dendritic actin networks in lamellipodia.

Cell patterning by secretion-induced plasma membrane flows

The paper shows that exocytosis-induced membrane flows restrict Cdc42 activity zones by dragging proteins and forming negative feedback in fission yeast.

Insights into actin polymerization and nucleation using a coarse grained model

This study uses a coarse-grained model to simulate actin polymerization and nucleation, revealing binding dynamics and structural configurations at barbed and pointed ends.

Cdc42 GTPase Activating Proteins (GAPs) Maintain Generational Inheritance of Cell Polarity and Cell Shape in Fission Yeast

This study shows that Cdc42 GAP proteins Rga4 and Rga6 mediate generational inheritance of cell polarity and shape in fission yeast through asymmetric distribution during cell division.

Organization of Associating or Crosslinked Actin Filaments in Confinement

This study uses computer simulations to show how confinement and attractive interactions between actin filaments can lead to ring formation in cells.

Automated Tracking of Biopolymer Growth and Network Deformation with TSOAX

The paper introduces an open-source software tool for automated tracking of biopolymer networks in 2D and 3D using stretching open active contours, demonstrating its application in live cell studies.

Computational modeling highlights disordered Formin Homology 1 domain’s role in profilin-actin transfer

The paper uses simulations to show FH1 domains facilitate profilin-actin transfer, with flexibility and proximity to FH2 affecting efficiency.