J. Xue

Dynamin 1xA interacts with Endophilin A1 via its spliced long C-terminus for ultrafast endocytosis

This study identifies a phospho-regulated interaction between Dyn1xA and Endophilin A1 via a unique C-terminal extension, essential for ultrafast endocytosis.

Multilevel regulation of NF-kappa B signaling by NSD2 suppresses Kras-driven pancreatic tumorigenesis

This study shows NSD2 acts as a tumor suppressor in Kras-driven pancreatic cancer by regulating NF-kappa B signaling through multiple mechanisms.

68Ga-Bisphosphonates for the Imaging of Extraosseous Calcification by Positron Emission Tomography

This study compares 68Ga-labelled bisphosphonate and 18F-fluoride PET tracers for imaging extraosseous calcification in a rat model, finding that the bisphosphonate tracer detects a wider range of calcium minerals more sensitively.

Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

A host E3 ubiquitin ligase regulates Salmonella virulence by targeting an SPI-2 effector involved in SIF biogenesis

The paper identifies TRIM32 as a host E3 ubiquitin ligase that targets SseK3, an SPI-2 effector, to restrict Salmonella-induced filament biogenesis and replication.

Alizarin Red fluorescence imaging for nano calcification

This study evaluates Alizarin Red as a fluorescent staining agent for visualizing nano and micro calcified structures in biological samples, finding it to be simple, reliable, effective, and cost-efficient.

Altered virome structrue and function characterization in Helicobacter pylori-driven colorectal carcinogenesis and H. pylori eradication

This study characterizes changes in the gut virome during H. pylori-driven colorectal carcinogenesis and after eradication, showing expanded temperate phages and persistent antibiotic resistance genes.

The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background

This study evaluates how compound interventions and genetic background affect healthspan and lifespan in C. elegans under stress conditions.

Phosphoantigens are Molecular Glues that Promote Butyrophilin 3A1/2A1 Association Leading to Vγ9Vδ2 T Cell Activation

The paper shows phosphoantigens glue BTN3A1 and BTN2A1 together, initiating gamma-delta T cell activation through intracellular signaling.

Histone demethylase UTX regulates glioblastoma progression through affecting periostin expression

This study shows that UTX promotes glioblastoma progression by upregulating periostin expression, and its knockdown inhibits tumor growth and promotes apoptosis.

KRAS G12D can be targeted by potent salt-bridge forming inhibitors

This study identifies potent inhibitors targeting KRAS G12D via a salt-bridge interaction, showing efficacy in reducing tumor volume and synergizing with anti-PD-1 therapy.

Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain specific lifespan and health effects in Caenorhabditis nematodes

This study evaluates the lifespan and health effects of five compounds in Caenorhabditis nematodes, finding species- and strain-specific responses, assay-dependent outcomes, and uncoupling of lifespan and health effects.

TMEM120 is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase

The paper presents the cryo-EM structure of TMEM120A, revealing it binds coenzyme A and shares structural features with ELOVL fatty acid elongase, suggesting a potential role in fatty acid metabolism rather than mechanosensation.

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

Association of CD44-/CD24- Breast Cancer Cells with Late Stage Tumor Recurrence

This study links CD44-/CD24- breast cancer cells to late-stage tumor recurrence and identifies RHBDL2 as a regulator of CSC conversion.

Lymph flow directs rapid neutrophil positioning in the lymph node in infection

This study shows that lymph flow directs neutrophil migration in lymph nodes during infection by transporting chemokines, and impaired flow leads to persistent infection.

The immunodominant and neutralization linear epitopes for SARS-CoV-2

This study identifies immunodominant and neutralizing epitopes on SARS-CoV-2 proteins through computational simulation and experimental validation in mice.

Fitness benefit plays a vital role in the retention of the Pi-ta susceptible alleles

The paper shows that susceptible Pi-ta alleles are retained due to their fitness benefit by acting as an off-switch for immune signaling.

Nuclear and cellular, micro and nano calcification in Alzheimer's disease patients and correlation to phosphorylated Tau.

This study examines brain calcification in Alzheimer's disease patients using microscopy, showing microcalcification associated with pTau and suggesting a new mechanism of brain cell damage.

Lack of Reinfection in Rhesus Macaques Infected with SARS-CoV-2

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in Rhesus macaques

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

Open microfluidic coculture reveals paracrine signaling from human kidney epithelial cells promotes kidney specificity of endothelial cells

This study uses an open microfluidic coculture system to show that human kidney epithelial cells promote kidney-specific gene expression in endothelial cells through paracrine signaling.

The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

Automated Lifespan Determination Across Caenorhabditis Strains and Species Reveals Assay-Specific Effects of Chemical Interventions

The paper compares manual and automated lifespan assays in Caenorhabditis strains, finding that automated methods reproduce results but show assay-specific effects of chemical interventions.

Arginine-GlcNAcylation of death domain and NleB/SseK proteins is crucial for bacteria pathogenesis by regulating host cell death

This study identifies arginine-GlcNAcylation as a mechanism by which bacterial effectors NleB and SseKs modulate host death receptor signaling to promote pathogenesis.

Single Nanoparticle Tracking Reveals Efficient Long-Distance Undercurrent Transport above Swarming Bacteria

The paper uses gold nanorods to track fluid dynamics above swarming bacteria, revealing superdiffusive transport flows that enable long-range material transport and population-level communication.

The Female Heart: Sex Differences in the Dynamics of ECG in Response to Stress

This study shows that mental stress causes different heart rate variability responses in males and females, with males showing increased heart rate and decreased high frequency power, while females show increased high frequency power and increased entropy.