Activation of the Cpx-envelope stress response system promotes tolerance to antibacterials delivered by arginine-rich peptides and aminoglycosides in Escherichia coli
J. Frimodt-Moller, A. Koulouktsis, G. Charbon, M. Otterlei, P. E. Nielsen, A. Lobner-Olesen
The paper shows that Escherichia coli resistance to arginine-rich CPP-PNA conjugates involves the constitutively active Cpx-envelope stress response system, which reduces membrane potential and increases tolerance to aminoglycosides.
bioRxiv · Aug 31, 2020 · PreprintMicrobiology