Clonally-Expanded, Thyrotoxic Autoimmune Mediator CD8+ T cells Driven by IL21 Contribute to Checkpoint Inhibitor Thyroiditis
M. G. Lechner, Z. Zhou, A. T. Hoang, N. Huang, J. Ortega, L. N. Scott, H.-C. Chen, A. Y. Patel, R. Y. Tafti, K. Kim, W. Hugo, P. Famini, A. Drakaki, A. Ribas, T. E. Angell, M. A. Su
The paper identifies clonally expanded CD8+ T cells driven by IL21 in ICI-thyroiditis using scRNA-seq and validates their role in thyroid inflammation.
bioRxiv · Dec 18, 2022 · PreprintImmunology