N. Huang

Selective degradation of multimeric proteins via chemically induced proximity to TRIM21

This study identifies acepromazine as a compound that selectively degrades multimeric proteins via TRIM21 activation, offering a new strategy for targeting disease-related protein assemblies.

CEP44 is required for maintaining centriole duplication and spindle integrity

This study identifies CEP44's role in preventing centriole overduplication and maintaining spindle integrity, linking it to breast carcinoma prognosis.

The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

The study identifies age-related differences in nasal epithelial cell responses to SARS-CoV-2 infection, showing distinct progenitor cell dynamics in children and elderly.

Clonally-Expanded, Thyrotoxic Autoimmune Mediator CD8+ T cells Driven by IL21 Contribute to Checkpoint Inhibitor Thyroiditis

The paper identifies clonally expanded CD8+ T cells driven by IL21 in ICI-thyroiditis using scRNA-seq and validates their role in thyroid inflammation.

Survival intravascular photoacoustic imaging of lipid-rich plaque in cholesterol fed rabbits

This study demonstrates survival intravascular photoacoustic imaging of lipid-rich atherosclerotic plaques in a rabbit model using MRI-guided IVPA catheter, validated by histology.

Hepatobiliary organoids derived from leporids support the replication of hepatotropic lagoviruses

This study demonstrates that hepatobiliary organoids from leporids support replication of hepatotropic lagoviruses, with species-specific tropism observed in different host organoids.

An integrated cell atlas of the human lung in health and disease

The paper integrates 46 single-cell datasets to create the Human Lung Cell Atlas, improving cell annotation and uncovering gene modules linked to demographics and anatomy.

A spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche

The paper creates a spatial multi-omics lung atlas identifying novel cell types and a survival niche for IgA-secreting plasma cells in submucosal glands.

α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization

This study identifies α-taxilin and γ-taxilin as new components of centriolar subdistal appendages, showing their role in microtubule anchorage and spindle orientation.

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture across the human body

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

Cells of the human intestinal tract mapped across space and time

The paper maps human intestinal cell lineages across development and disease, identifying new cell types and functions related to inflammation and immunity.

Frequent intergenotypic recombination between the non-structural and structural genes is a major driver of epidemiological fitness in caliciviruses

This study identifies frequent recombination between non-structural and structural genes in lagoviruses as a key driver of epidemiological fitness, leading to the emergence of multiple recombinant variants that outcompete parental strains.

Poised cell circuits in human skin are activated in disease

The paper creates a single-cell atlas of human skin, showing how cell circuits change in inflammatory diseases like atopic dermatitis and psoriasis.

A Fast Lysine Cross-linker DOPA Enables Mass Spectrometry Analyses of Protein Unfolding and Weak Protein-protein Interactions

This study introduces a fast lysine cross-linker DOPA for mass spectrometry analyses, showing it enables rapid protein cross-linking and captures dynamic conformational changes and weak protein-protein interactions.

Identification of PDE6D as a potential target of sorafenib via PROTAC technology

This study identifies PDE6D as a potential target of sorafenib using PROTAC technology and proteomic analysis.

Quantify the requirements to achieve grain Zn biofortification of high-yield wheat on calcareous soils

This study quantifies the Zn uptake and distribution requirements needed to achieve high grain Zn concentration in high-yield wheat on low-Zn calcareous soils.

Single cell transcriptional characterization of human megakaryocyte lineage commitment and maturation

This study uses single-cell RNA sequencing to analyze human bone marrow HSCs and MKs, identifying MK primed HSC clusters and transcriptional changes during MK maturation and their association with myocardial infarction.

Carrion flies as sentinels for monitoring rabbit calicivirus activity in Australia

This study uses carrion flies to monitor rabbit calicivirus activity in Australia, finding good correlation with rabbit samples and proposing a less biased surveillance method.

Structural insight into the mechanism of 4-aminoquinolines selectivity for the alpha2A-adrenoceptor

This study investigates the selectivity of 4-aminoquinolines for the alpha2A-adrenoceptor using docking, molecular dynamics, and mutagenesis to identify binding sites and affinity determinants.

The discovery of three new hare lagoviruses reveals unexplored viral diversity in this genus

The paper discovers three new hare lagoviruses in Australian hares, highlighting unexplored viral diversity and suggesting extensive unsampled diversity in the genus.

A strain-specific multiplex RT-PCR for Australian rabbit haemorrhagic disease viruses uncovers a new recombinant virus variant in rabbits and hares

The paper develops strain-specific RT-PCR assays to detect lagoviruses in Australia and identifies a novel recombinant virus variant combining genes from GI.1a-Aus and GI.2.