Author

P. G. Stockley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

N. Patel· 3 shared R. Twarock· 3 shared S. Clark· 2 shared A. J. P. Scott· 1 shared A. Steinauer· 1 shared C. P. Mata· 1 shared D. Hilvert· 1 shared D. P. Maskell· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

N. Patel

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

In vitro Functional Analysis of pgRNA Sites Regulating Assembly of Hepatitis B Virus.

N. Patel, S. Clark, E. U. Weiss, C. P. Mata, J. Bohon, E. Farquhar, D. P. Maskell, N. A. Ranson, R. Twarock, P. G. Stockley

The paper investigates RNA sequence/structure motifs regulating HBV genome assembly in vitro, showing their role in nucleocapsid formation and confirming interactions via X-ray RNA footprinting.

bioRxiv · Sep 8, 2021Microbiology

Dysregulation of Hepatitis B Virus Nucleocapsid Assembly with RNA-directed Small Ligands

N. Patel, F. Abulwerdi, F. Fatehi, I. Manfield, S. Le Grice, J. S. Schneekloth, R. Twarock, P. G. Stockley

The paper identifies small ligands that bind RNA packaging signals in Hepatitis B Virus, inhibiting nucleocapsid assembly and suggesting new anti-viral drug targets.

bioRxiv · Aug 10, 2021 · PreprintMicrobiology

Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein

S. Tetter, N. Terasaka, A. Steinauer, R. J. Bingham, S. Clark, A. J. P. Scott, N. Patel, M. Leibundgut, E. Wroblewski, N. Ban, P. G. Stockley, R. Twarock, D. Hilvert

This study evolved a bacterial protein into an artificial nucleocapsid that packages and protects mRNA, revealing evolutionary parallels to viruses and potential applications in vaccine delivery.

bioRxiv · Dec 23, 2020Biochemistry