Author

P. Germain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

W. Bourguet· 3 shared A. Barducci· 2 shared A. Boulahtouf· 2 shared A. le Maire· 2 shared F. Allemand· 2 shared N. Sibille· 2 shared P. Bernado· 2 shared A. Ancelin· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiophysics

W. Bourguet

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Author profile →

3 papers

Recent·Most cited

Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex

J. Gruszczyk, L. Grandvuillemin, J. Lai-Kee-Him, M. Paloni, C. G. Savva, P. Germain, M. Grimaldi, A. Boulahtouf, H.-S. Kwong, J. Bous, A. Ancelin, C. Bechara, A. Barducci, P. Balaguer, W. Bourguet

The paper presents a cryo-EM structure of the AHR complex bound to a ligand, revealing structural details of its activation mechanism and ligand-binding specificity.

bioRxiv · May 17, 2022Biochemistry

Structural insights into the cooperative interaction of the intrinsically disordered co-activator TIF2 with retinoic acid receptor heterodimer (RXR/RAR)

L. Senicourt, A. le Maire, F. Allemand, J. E. Carvalho, L. Guee, P. Germain, M. Schubert, P. Bernado, W. Bourguet, N. Sibille

The paper determines the structural features of TIF2NRID and its cooperative binding to RXR/RAR, revealing partially structured regions and the role of flanking sequences.

bioRxiv · Oct 28, 2020Biophysics

Interplay of protein disorder in retinoic acid receptor heterodimer and its corepressor regulates gene expression

T. N. Cordeiro, N. Sibille, P. Germain, P. Barthe, A. Boulahtouf, F. Allemand, R. Bailly, V. Vivat, C. Ebel, A. Barducci, W. Bourguet, A. le Maire, P. Bernado

This study shows that the structural dynamics of the H12 helix in RXR/RAR heterodimers and the intrinsic disorder of N-CoR regulate gene expression through conformational changes and corepressor complex formation.

bioRxiv · Oct 25, 2018Biophysics