Author

C. Bechara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1

Frequent Co-Authors

S. Granier· 5 shared C. Leyrat· 4 shared T. Durroux· 4 shared E. Del Nero· 3 shared O. Otun· 3 shared S. Jeannot· 3 shared X. Cong· 3 shared C. M. Grison· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersBiochemistry

S. Granier

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Author profile →

6 papers

Recent·Most cited

Physical interaction with Ephrin B1 promotes CXCR4 intracellular localization and oncogenic potential

A. Rabbito, O. Otun, A. Fumagalli, M. Seveno, S. Galant, M. Counson, T. Durroux, C. Bechara, M. J. Smit, S. Granier, M. Szpakowska, A. Chevigne, S. Chaumont-Dubel, P. Marin

This study identifies Ephrin B1 as a key mediator of CXCR4 tumorigenic signaling by promoting its intracellular localization and inhibiting surface expression and signaling.

bioRxiv · Jul 10, 2024Biochemistry

Conformational dynamics underlying Atypical Chemokine Receptor 3 activation

O. Otun, C. Aljamous, E. Del Nero, M. Arimont-Segura, R. Bosma, B. Zarzycka, T. Girbau, C. Leyrat, C. de Graaf, R. Leurs, T. Durroux, S. Granier, X. Cong, C. BECHARA

This study investigates the conformational dynamics of ACKR3 activation using HDX-MS and molecular dynamics simulations, revealing key structural changes and ligand binding mechanisms.

bioRxiv · Jul 17, 2023 · PreprintBiochemistry

Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex

J. Gruszczyk, L. Grandvuillemin, J. Lai-Kee-Him, M. Paloni, C. G. Savva, P. Germain, M. Grimaldi, A. Boulahtouf, H.-S. Kwong, J. Bous, A. Ancelin, C. Bechara, A. Barducci, P. Balaguer, W. Bourguet

The paper presents a cryo-EM structure of the AHR complex bound to a ligand, revealing structural details of its activation mechanism and ligand-binding specificity.

bioRxiv · May 17, 2022Biochemistry

Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins

C. Leyrat, S. Granier, T. Durroux, C. Bechara, S. Jeannot, F. Peysson, C. M. Grison, P. Verdie, L. Brunel, F. Hoh, X. Cong, O. Otun, P. Lambey

This study investigates how Staphylococcus aureus leukotoxins recognize chemokine receptors, identifying sulfotyrosine binding sites and proposing structural models for receptor-toxin interactions.

bioRxiv · Aug 5, 2021Biochemistry

Discovery and mechanism of action of small molecule inhibitors of ceramidases

S. Granier, R. D. Healey, E. Saied, X. Cong, G. Karsai, L. Gabellier, J. Saint-Paul, E. Del Nero, S. Jeannot, M. Drapeau, S. Fontanel, D. Maurel, S. Basu, C. LEYRAT, G. Bossis, , C. Arenz

The paper discovers small molecule inhibitors of alkaline ceramidase 3 using fluorescent substrates and characterizes their mechanism of action.

bioRxiv · Jun 15, 2021Biochemistry

Mechanisms of GPCR hijacking by Staphylococcus aureus

C. M. Grison, C. Leyrat, P. Lambey, S. Jeannot, E. Del Nero, S. Fontanel, F. Peysson, J. Heuninck, R. Sounier, T. Durroux, S. Granier, C. Bechara

This study investigates how Staphylococcus aureus leukotoxins HlgA and HlgB interact with ACKR1, altering its structure and function to aid bacterial growth and immune evasion.

bioRxiv · Feb 8, 2021 · PreprintBiochemistry