P. J. Houghton

This study shows that MEK inhibition sensitizes fusion-negative rhabdomyosarcoma to ionizing radiation via SNAI2 downregulation, leading to increased apoptosis and tumor regression.

This study identifies SNAI2 as a repressor of BIM, protecting rhabdomyosarcoma from ionizing radiation through a P53-independent mechanism.

The paper uses single-cell RNA sequencing to identify distinct cellular responses to EWSR1-FLI1 down-regulation in Ewing sarcoma, revealing dormancy and stem-like features associated with drug resistance.

This study shows EWS-FLI-1 promotes IGF signaling by inducing pappalysin-1, which degrades IGFBPs and enhances IGF bioavailability, making pappalysin-1 a potential therapeutic target in Ewing sarcoma.