M. S. Ignatius

The 3D chromatin landscape of rhabdomyosarcoma

This study maps the 3D chromatin structure of rhabdomyosarcoma subtypes using Hi-C, revealing structural variations and gene regulatory patterns.

Sensitization to Ionizing Radiation by MEK inhibition is Dependent on SNAI2 in Fusion-negative Rhabdomyosarcoma

This study shows that MEK inhibition sensitizes fusion-negative rhabdomyosarcoma to ionizing radiation via SNAI2 downregulation, leading to increased apoptosis and tumor regression.

Defining function of wild-type and patient specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma

The paper defines the role of wild-type and patient-specific TP53 mutations in ERMS using zebrafish models, showing tp53 loss increases tumor initiation and identifying mutation-specific effects on tumor development.

SNAI2-mediated direct repression of BIM protects rhabdomyosarcoma from ionizing radiation

This study identifies SNAI2 as a repressor of BIM, protecting rhabdomyosarcoma from ionizing radiation through a P53-independent mechanism.

Single-cell RNA Profiling Identifies Diverse Cellular Responses to EWSR1-FLI1 Down-regulation in Ewing Sarcoma

The paper uses single-cell RNA sequencing to identify distinct cellular responses to EWSR1-FLI1 down-regulation in Ewing sarcoma, revealing dormancy and stem-like features associated with drug resistance.