Author

N. R. Hensch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

L. Wang· 3 shared M. S. Ignatius· 3 shared E. Y. Chen· 2 shared J. Chen· 2 shared K. Baxi· 2 shared K. Bondra· 2 shared P. J. Houghton· 2 shared P. Sreenivas· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCancer Biology

L. Wang

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Author profile →

3 papers

Recent·Most cited

Sensitization to Ionizing Radiation by MEK inhibition is Dependent on SNAI2 in Fusion-negative Rhabdomyosarcoma

N. R. Hensch, K. Bondra, L. Wang, P. Sreenivas, X. R. Zhao, P. Modi, A. V. Vaseva, P. J. Houghton, M. S. Ignatius

This study shows that MEK inhibition sensitizes fusion-negative rhabdomyosarcoma to ionizing radiation via SNAI2 downregulation, leading to increased apoptosis and tumor regression.

bioRxiv · May 2, 2022Cancer Biology

Defining function of wild-type and patient specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma

J. Chen, K. Baxi, A. E. Lipsitt, N. R. Hensch, L. Wang, A. Baudin, D. G. Robledo, A. Bandyopadhyay, A. Sugalski, A. K. Challa, A. R. Gilbert, G. E. Tomlinson, P. Houghton, E. Y. Chen, D. S. Libich, M. S. Ignatius

The paper defines the role of wild-type and patient-specific TP53 mutations in ERMS using zebrafish models, showing tp53 loss increases tumor initiation and identifying mutation-specific effects on tumor development.

bioRxiv · Apr 21, 2021Cancer Biology

SNAI2-mediated direct repression of BIM protects rhabdomyosarcoma from ionizing radiation

L. Wang, N. R. Hensch, K. Bondra, P. Sreenivas, X. R. Zhao, J. Chen, K. Baxi, R. M. Campos, B. Gryder, S. Pomella, R. Rota, E. Y. Chen, J. Khan, P. J. Houghton, M. S. Ignatius

This study identifies SNAI2 as a repressor of BIM, protecting rhabdomyosarcoma from ionizing radiation through a P53-independent mechanism.

bioRxiv · Jan 25, 2021Cancer Biology