P. J. Huis in 't Veld

This study shows that the Ndc80 loop facilitates Ndc80-Ndc80 interactions, which are essential for stable kinetochore-microtubule attachments and proper chromosome congression.

This paper introduces a DNA origami nanospring to estimate microtubule-generated forces using fluorescence microscopy and validates it against optical trapping.

The paper measures strain stiffening of Ndc80 complexes under tension from depolymerizing microtubules, showing it is robust to mutations and linked to structural features and thermal fluctuations.

The paper determines the cryo-EM structure of the human FERRY Rab5 effector complex and shows Fy-2 acts as a binding hub for subunits and mRNA/Rab5.

The paper shows that NDC80 clustering increases microtubule binding affinity and enables force-dependent modulation of kinetochore-microtubule attachments.