Author

P. Joseph Aruscavage

University of Utah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Brenda BassiD· 3 shared Claudia D. ConsalvoiD· 2 shared Elaina P. BoyleiD· 2 shared Parker J. NicholsiD· 1 shared Peter S SheniD· 1 shared Supraja RanganathaniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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3 shared papersImmunology

Brenda BassORCID

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3 papers

Recent·Most cited

C. elegans Dicer stacks with the RIG-I-like receptor DRH-1 to cleave dsRNA

Claudia D. Consalvo, Parker J. Nichols, Elaina P. Boyle, P. Joseph Aruscavage, Peter S Shen, Brenda Bass

The paper reports cryo-EM structures of the C. elegans antiviral complex DCR-1·DRH-1·RDE-4, showing how these proteins stack and interact to cleave dsRNA.

bioRxiv · Aug 20, 2026 · PreprintImmunology

Reconstitution of antiviral Dicer activity in vitro reveals distinct contributions of RDE-4 dsRNA-binding motifs

Elaina P. Boyle, P. Joseph Aruscavage, Claudia D. Consalvo, Brenda Bass

This study reconstitutes the antiviral Dicer complex in vitro to show RDE-4 stabilizes and activates it, with distinct roles for dsRBM2 and dsRBM3 in ATP hydrolysis and dsRNA cleavage.

RNA · May 27, 2026Peer-reviewedBiochemistry

Characterization of Orsay virus replication intermediates in Caenorhabditis elegans reveals links to antiviral RNA interference

Supraja Ranganathan, P. Joseph Aruscavage, Brenda Bass

This study characterizes Orsay virus replication intermediates in C. elegans, revealing their connection to antiviral RNA interference pathways.

Molecular Biology of the Cell · Feb 18, 2026Peer-reviewedImmunology