Author

Claudia D. Consalvo

University of UtahORCID 0000-0003-2038-4315Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:C. elegans· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:structural biology· 1

Frequent Co-Authors

Brenda BassiD· 3 shared Elaina P. BoyleiD· 2 shared P. Joseph Aruscavage· 2 shared Peter S SheniD· 2 shared Adedeji M. AderounmuiD· 1 shared Josephine Maus-ConniD· 1 shared Parker J. NicholsiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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3 shared papersBiochemistry

Brenda BassORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintAug 20, 2026

C. elegans Dicer stacks with the RIG-I-like receptor DRH-1 to cleave dsRNA

Claudia D. Consalvo, Parker J. Nichols, Elaina P. Boyle…·Brenda Bass

The paper reports cryo-EM structures of the C. elegans antiviral complex DCR-1·DRH-1·RDE-4, showing how these proteins stack and interact to cleave dsRNA.

DOI 10.64898/2026.08.16.745104

C. elegansstructural biology

𝕏 PostBluesky

BiochemistryRNAPeer-reviewedMay 27, 2026

Reconstitution of antiviral Dicer activity in vitro reveals distinct contributions of RDE-4 dsRNA-binding motifs

Elaina P. Boyle, P. Joseph Aruscavage, Claudia D. Consalvo, Brenda Bass

This study reconstitutes the antiviral Dicer complex in vitro to show RDE-4 stabilizes and activates it, with distinct roles for dsRBM2 and dsRBM3 in ATP hydrolysis and dsRNA cleavage.

DOI 10.1261/rna.080917.125

C. elegansexperimental assay

𝕏 PostBluesky

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedMay 28, 2025

Biochemical and structural basis of Dicer helicase function unveiled by resurrecting ancient proteins

Adedeji M. Aderounmu, Josephine Maus-Conn, Claudia D. Consalvo…·Brenda Bass

This study reconstructs ancient Dicer helicases to uncover how ATP hydrolysis drives dsRNA translocation and cleavage, revealing evolutionary changes in helicase function across species.

4 citations

experimental assaychromatin & epigenetic regulation

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