Peter S Shen

The paper reports cryo-EM structures of the C. elegans antiviral complex DCR-1·DRH-1·RDE-4, showing how these proteins stack and interact to cleave dsRNA.

The paper presents a cryo-EM structure of the RQC complex from budding yeast, revealing its mechanism for removing stalled peptides from the ribosome.

This study uses cryo-EM and biochemistry to show how disease-causing mutations in Gβ5 disrupt its folding by CCT, leading to trapped intermediates and neurological disease.

This study reconstructs ancient Dicer helicases to uncover how ATP hydrolysis drives dsRNA translocation and cleavage, revealing evolutionary changes in helicase function across species.