Parker J. Nichols

The paper reports cryo-EM structures of the C. elegans antiviral complex DCR-1·DRH-1·RDE-4, showing how these proteins stack and interact to cleave dsRNA.

This study shows ZBP1 cannot convert unmodified dsRNA to Z-conformation, unlike ADAR1, revealing a competitive mechanism between these proteins in immune responses.

The study shows that Z domain mutations in ADAR1p150 slightly reduce A-to-I editing, likely due to mislocalization rather than editing specificity loss, and suggests phenotypes may stem from ZBP1 inhibition.