Author

P. Karras

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J.-C. Marine· 4 shared D. Lambrechts· 3 shared E. Leucci· 3 shared O. Bechter· 3 shared D. Pedri· 2 shared F. Bosisio· 2 shared F. Rambow· 2 shared G. Bervoets· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

J.-C. Marine

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4 papers

Recent·Most cited

A TCF4/BRD4-dependent regulatory network confers cross-resistance to targeted and immune checkpoint therapy in melanoma

J. Pozniak, D. Pedri, E. Landeloos, Y. Van Herck, A. Antoranz, P. Karras, A. Nowosad, S. Makhzami, G. Bervoets, M. Dewaele, L. Vanwynsberghe, S. Cinque, S. Kint, K. Vandereyken, T. Voet, , J.-C. Marine

This study identifies a TCF4/BRD4-dependent regulatory network that drives cross-resistance to ICB and targeted therapy in melanoma by analyzing scRNA-seq data from a longitudinal cohort.

bioRxiv · Aug 11, 2022 · PreprintCancer Biology

Heterogeneity in PHGDH protein expression potentiates cancer cell dissemination and metastasis

M. Rossi, G. Doglioni, L. Bornes, D. Broekart, M. Planque, J. Fernandez-Garcia, G. Rinaldi, J. Van Elsen, D. Nittner, C. Jauset, F. Rizzollo, C. Riera Domingo, M. Orth, L. E. Dobrolecki, T. Van Brussel, , S.-M. Fendt

This study identifies PHGDH protein expression heterogeneity as a driver of breast cancer metastasis by altering metabolic pathways and promoting dissemination.

bioRxiv · Jan 24, 2021Cancer Biology

A neural crest stem cell-like state drives nongenetic resistance to targeted therapy in melanoma

O. Marin-Bejar, A. Rogiers, M. Dewaele, J. Femel, P. Karras, J. Pozniak, G. Bervoets, N. Van Raemdonck, D. Pedri, T. Swings, J. Demeulemeester, S. Vander Borght, F. Bosisio, J. J. van den Oord, I. Vanden Bempt, , J.-C. Marine

This study identifies a neural crest stem cell-like state in melanoma minimal residual disease that drives nongenetic resistance to MAPK-targeted therapy and shows that targeting FAK/SRC signaling can delay relapse.

bioRxiv · Dec 15, 2020 · PreprintCancer Biology

Activation of the Integrated Stress Response in drug-tolerant melanoma cells confers vulnerability to mitoribosome-targeting antibiotics.

R. Vendramin, A. Konnova, S. Adnane, S. Cinque, V. Katopodi, Z. Knezevic, P. Karras, E. Demesmaeker, F. M. Bosisio, L. Rizzotto, O. Bechter, J.-C. Marine, E. Leucci

This study shows that activating the Integrated Stress Response in drug-tolerant melanoma cells makes them vulnerable to mitoribosome-targeting antibiotics, offering a new therapeutic strategy.

bioRxiv · Jun 26, 2020Cancer Biology