This study develops a repeat-biopsy model in mice combined with ultra-fast cycling technology to analyze immune response changes in gliomas over time and in response to treatment.

bioRxiv · Jun 15, 2024Cancer Biology

PI(3,5)P2 Controls the Signaling Activity of Class I PI3K

J. Sun, J. Zalejski, S. Song, A. Sharma, W. Wang, Y. Hu, W.-T. Lo, P. Koch, J. Singh, I. Singaram, B. An, J. Zhao, L.-W. Gong, V. Haucke, R. Gao, W. Cho

This study identifies PI(3,5)P2 as a regulator of Class I PI3K activity by interacting with its p85 subunit, revealing a feedback mechanism that impacts cancer and tissue repair.

bioRxiv · Jan 25, 2023 · PreprintBiochemistry

A multiplexed cell-free assay to screen for antimicrobial peptides in double emulsion droplets

N. Nuti, P. Rottmann, A. Stucki, P. Koch, S. Panke, P. S. Dittrich

This paper introduces a microfluidic system for cell-free production and screening of antimicrobial peptides based on their membrane specificity using double emulsion droplets.

bioRxiv · Nov 17, 2021Bioengineering

The analysis of epigenomic evolution

A. Sahm, P. Koch, S. Horvath, S. Hoffmann

The paper applies phylogenetic methods to epigenetic data, showing DNA methylation conservation and its correlation with transcription factor binding density in great apes.

bioRxiv · Mar 3, 2021Evolutionary Biology