Author

V. Haucke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Organism:human· 4 Assay:imaging· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

M. Lehmann· 4 shared C. Schmied· 2 shared D. Puchkov· 2 shared H. Ewers· 2 shared A. Dickey· 1 shared A. Grindel· 1 shared A. Heuhsen· 1 shared A. Klemt· 1 shared

Activity by Year

2021-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersCell Biology

M. Lehmann

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Septin-associated PIPKIγ splice variants drive centralspindlin association with the midbody via PI(4,5)P2

G. Russo, N. Hümpfer, N. Jaensch, S. Restel, C. Schmied, F. Heyd, M. Lehmann, V. Haucke, H. Ewers, M. Krauss

This study identifies septin-associated PIPKIγ splice variants as essential for midbody organization by generating PI(4,5)P2 required for centralspindlin recruitment and septin-microtubule association.

bioRxiv · Feb 22, 2024 · PreprintCell Biology

Turnover of PPP1R15A mRNA encoding GADD34 controls the molecular memory of the cellular integrated stress response

V. Magg, A. Manetto, K. Kopp, C. C. Wu, M. Naghizadeh, D. Lindner, L. Eke, J. Welsch, S. M. Kallenberger, J. Schott, V. Haucke, N. Locker, G. Stoecklin, A. Ruggieri

The paper identifies a mechanism by which PPP1R15A mRNA stability regulates GADD34 expression, controlling the cellular integrated stress response's memory and adaptation to stress.

bioRxiv · Nov 11, 2023 · PreprintCell Biology

ARF1 compartments direct cargo flow via maturation into recycling endosomes

A. Stockhammer, P. Adarska, V. Natalia, A. Heuhsen, A. Klemt, G. Bregu, S. Harel, C. Rodilla-Ramirez, C. Spalt, E. Oezsoy, P. Leupold, A. Grindel, E. Fox, J. O. Mejedo, A. Zehtabian, , F. Bottanelli

The paper identifies two functionally distinct ARF1 compartments involved in post-Golgi sorting and endocytic recycling, challenging the classical vesicle shuttling model.

bioRxiv · Oct 27, 2023Cell Biology

OrgaMapper: A robust and easy-to-use workflow for analyzing organelle positioning

C. Schmied, M. Ebner, P. F. Samso, V. Haucke, M. Lehmann

The paper introduces OrgaMapper, a workflow for analyzing organelle positioning, demonstrating its robustness against common challenges in assessing positioning phenotypes.

bioRxiv · Jul 10, 2023Cell Biology

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

T. Aguirre, G. L. Dornan, S. Hostachy, M. Neuenschwander, C. Seyffarth, V. Haucke, A. Schuetz, J. P. von Kries, D. Fiedler

The paper identifies FMP-201300 as a potent and selective inhibitor for IP6K1 and IP6K2 with a valine gatekeeper mutation, revealing an allosteric mechanism of action.

bioRxiv · Apr 26, 2023Biochemistry

PI(3,5)P2 Controls the Signaling Activity of Class I PI3K

J. Sun, J. Zalejski, S. Song, A. Sharma, W. Wang, Y. Hu, W.-T. Lo, P. Koch, J. Singh, I. Singaram, B. An, J. Zhao, L.-W. Gong, V. Haucke, R. Gao, W. Cho

This study identifies PI(3,5)P2 as a regulator of Class I PI3K activity by interacting with its p85 subunit, revealing a feedback mechanism that impacts cancer and tissue repair.

bioRxiv · Jan 25, 2023 · PreprintBiochemistry

The molecular organization of flat and curved caveolae indicates bendable structural units at the plasma membrane.

C. Matthaeus, K. Sochacki, A. Dickey, D. Puchkov, V. Haucke, M. Lehmann, J. W. Taraska

This study identifies proteins involved in regulating caveolae shape using imaging techniques, revealing that dynamin is not directly involved in caveolae curvature.

bioRxiv · Mar 31, 2022 · PreprintCell Biology

Sulfonated rhodamines as impermeable labelling substrates for cell surface protein visualization

R. Birke, J. Ast, D. A. Roosen, B. Mathes, K. Rossmann, C. Huhn, B. Jones, M. Lehmann, V. Haucke, D. Hodson, J. Broichhagen

The paper introduces sulfonated rhodamines as impermeable dyes for cell surface protein labeling, validated in live cell imaging and STED nanoscopy.

bioRxiv · Mar 16, 2021 · PreprintBiochemistry