P. Kolb

Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity

This study identifies and characterizes Rhesus CMV-encoded Fcγ-binding glycoproteins, showing they delay antibody-mediated immune control during primary infection.

Differential recognition of opioid analgesics by μ opioid receptors: Predicted interaction patterns correlate with ligand-specific voltage sensitivity

The paper investigates how different opioid analgesics interact with μ opioid receptors, showing that ligand-specific voltage sensitivity correlates with predicted interaction patterns.

Circulating multimeric immune complexes drive immunopathology in COVID-19

This paper identifies soluble immune complexes as drivers of immunopathology in severe COVID-19 by enhancing FcγRIII activation and forming a vicious cycle of inflammation.

Detection and functional resolution of soluble multimeric immune complexes by a comprehensive FcγR reporter cell panel

This study establishes a comprehensive FcγR reporter cell assay to detect and quantify soluble immune complexes in experimental and clinical settings.

Human Cytomegalovirus antagonizes activation of Fcγ receptors II and III by distinct and synergizing modes of IgG manipulation

This paper shows HCMV uses gp34 and gp68 to block FcγR activation by different mechanisms that work together to evade antibody-mediated immunity.

GPCRmd uncovers the dynamics of the 3D-GPCRome

GPCRmd provides an online platform for visualizing and analyzing GPCR molecular dynamics simulations, demonstrating its utility through analyses of internal water networks and sodium ion interactions.

FK506-binding protein 13 expression is upregulated in interstitial lung disease and correlated with clinical severity: a potentially protective role.

This study shows FKBP13 is upregulated in interstitial lung diseases and correlates with disease severity, suggesting a protective role against fibrosis.