Mechanisms involved in the active secretion of CTX-M-15 β-lactamase by pathogenic E. coli ST131
S. Rangama, I. D. E. A. Lidbury, J. M. Holden, C. Borsetto, A. R. J. Murphy, P. M. Hawkey, E. M. H. Wellington
This study identifies CTX-M-15 β-lactamase as an actively secreted enzyme by E. coli ST131 that provides a protective effect against cefotaxime, with secretion mediated through a Type I secretion system rather than outer membrane vesicles.
bioRxiv · Mar 31, 2021Microbiology