BioengineeringbioRxiv
CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary cells
M. G. Kluesner, W. S. Lahr, C.-L. Lonetree…·B. S. Moriarity
The paper compares CBE and ABE base editors for splice-site disruption in T-cells, finding CBEs more reliable and splice-donor targeting most effective.
DOI 10.1038/s41467-021-22009-2