S. C. Lee

The amino acid permease Byc1 is involved in calcineurin-dependent thermos-tolerance in Cryptococcus neoformans

This study identifies a link between calcineurin, the amino acid permease Byc1, and protein kinase A in Cryptococcus neoformans, showing their roles in thermotolerance and antifungal drug resistance.

The genomes and epigenomes of aquatic plants (Lemnaceae) promote triploid hybridization and clonal reproduction

This paper presents genome and epigenome analyses of Lemnaceae plants, identifying genes related to clonal reproduction and CO2 sequestration, and highlights their potential for biotechnology.

Darapladib, an inhibitor of Lp-PLA2, sensitizes cancer cells to ferroptosis by remodeling lipid metabolism

This study shows that darapladib, an Lp-PLA2 inhibitor, enhances ferroptosis in cancer cells by altering lipid metabolism and synergizes with GPX4 inhibitors to suppress tumor growth.

Genetic and Environmental interactions contribute to immune variation in rewilded mice

This study examines how genetics and environment interact to influence immune variation in rewilded mice, finding that genotype drives cytokine responses while genotype-environment interactions shape cellular composition.

Exploring the Neoantigen burden in Breast Carcinoma Patients

This study analyzes neoantigen burden in breast cancer patients using whole-exome and RNA sequencing, finding high patient-specificity and correlation with somatic mutations.

Clostridia isolated from helminth-colonized humans promote hatching of Trichuris muris

The paper isolates and characterizes Clostridia from helminth-colonized humans, showing they promote hatching of Trichuris muris eggs.

Gut Microbiome of Helminth Infected Indigenous Malaysians Is Context Dependent

The paper analyzes gut microbiomes of helminth-infected indigenous Malaysians, finding context-dependent effects of helminth infections and albendazole treatment on microbial diversity and composition.

Duplication and overexpression of the genes encoding a beta 1,3-glucan synthase confer the intrinsic resistance to echinocandin in Mucor circinelloides

This study identifies gene duplication and calcineurin-mediated overexpression of fks genes as mechanisms of intrinsic echinocandin resistance in Mucor circinelloides.

CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary cells

The paper compares CBE and ABE base editors for splice-site disruption in T-cells, finding CBEs more reliable and splice-donor targeting most effective.

A novel resistance pathway for calcineurin inhibitors in the human pathogenic Mucorales Mucor circinelloides

This paper identifies a novel resistance mechanism in Mucor circinelloides involving the bycA gene, which promotes yeast growth and resistance to calcineurin inhibitors through a cAMP-independent pathway.

Tornadic shear stress induces a transient, calcineurin-dependent hyper-virulent phenotype in Mucorales molds

This study shows that tornadic shear stress induces a transient, calcineurin-dependent hyper-virulent phenotype in Mucorales molds, with potential therapeutic implications for trauma-related mucormycosis.

Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression

This study uses transposon mutagenesis to identify genetic drivers of keratinocyte transformation and cutaneous squamous cell carcinoma progression in vivo, revealing both known and novel genes involved in the disease.

Establishment of Wolbachia strain wAlbB in Malaysian populations of Aedes aegypti for dengue control

The paper describes the release of Aedes aegypti mosquitoes carrying the wAlbB Wolbachia strain in Malaysia to reduce dengue incidence, showing successful establishment and reduced human dengue cases in some areas.

A Nanoemulsion as an Effective Treatment Against Human Pathogenic Fungi

This study demonstrates that the nanoemulsion NB-201 effectively inhibits growth of multiple human pathogenic fungi and reduces infection burden in a mouse model.

ABA-dependent and ABA-independent functions of RCAR5/PYL11 in response to cold stress

This study identifies ABA-dependent and ABA-independent roles of RCAR5/PYL11 in Arabidopsis cold stress response, showing its impact on seed germination and stomatal closure.

DeepTRIAGE: Interpretable and Individualised BiomarkerScores using Attention Mechanism for the Classification of Breast Cancer Sub-types

DeepTRIAGE classifies breast cancer sub-types and assigns individualised biomarker scores using an attention mechanism, revealing heterogeneity within luminal sub-types.

Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides

The paper identifies RNAi-dependent epimutation as a mechanism for broad antifungal resistance in Mucor circinelloides, showing it can silence multiple genes involved in antifungal metabolism.

A cross-cancer metastasis signature in the microRNA-mRNA axis of paired tissue samples

The paper identifies cross-cancer metastasis biomarkers by analyzing miRNA-mRNA expression in paired tumor samples across 11 cancer types.

Outbreak of invasive wound mucormycosis in a burn unit due to multiple strains of Mucor circinelloides f. circinelloides resolved by whole genome sequencing

This study used whole genome sequencing to investigate an outbreak of invasive wound mucormycosis in a burn unit, revealing multiple strains from an environmental reservoir rather than direct patient-to-patient transmission.

Type 2 diabetes promotes cell centrosome amplification and the role of AKT-ROS-dependent signalling of ROCK1 and 14-3-3σ

This study shows type 2 diabetes increases centrosome amplification in PBMCs through AKT-ROS-dependent activation of ROCK1 and 14-3-3σ.