Author

M. G. Kluesner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:CRISPR screen· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

B. R. Webber· 2 shared B. S. Moriarity· 2 shared W. S. Lahr· 2 shared A. A. Andrew· 1 shared A. K. Gilkey· 1 shared B. A. Smeester· 1 shared C.-L. Lonetree· 1 shared E. J. Eaton· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioengineering

B. R. Webber

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing

M. Wang, J. B. Krueger, A. K. Gilkey, E. M. Stelljes, M. G. Kluesner, E. J. Pomeroy, J. G. Skeate, N. J. Slipek, W. S. Lahr, P. N. Claudio Vazquez, Y. Zhao, E. J. Eaton, K. Laoharawee, B. R. Webber, B. S. Moriarity

This study enhances CAR-NK cell functionality using non-viral base editing and transposon integration, showing improved therapeutic potential in Burkitt's lymphoma models.

bioRxiv · Mar 5, 2024Bioengineering

CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary cells

M. G. Kluesner, W. S. Lahr, C.-L. Lonetree, B. A. Smeester, P. N. Claudio-Vazquez, S. P. Pitzen, M. J. Vignes, S. C. Lee, S. P. Bingea, A. A. Andrew, B. R. Webber, B. S. Moriarity

The paper compares CBE and ABE base editors for splice-site disruption in T-cells, finding CBEs more reliable and splice-donor targeting most effective.

bioRxiv · Apr 16, 2020Bioengineering