Author

P. P. Roux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

G. Lavoie· 4 shared E. K. Paluch· 2 shared A. Alkhoury· 1 shared A. Ayyaz· 1 shared A. Beautrait· 1 shared A. Malik· 1 shared A. Marinier· 1 shared A. Martinez-sanchez· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersCell Biology

G. Lavoie

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

14-3-3ζ regulates adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation

S. A. Rial, Z. You, A. Vivoli, D. Sean, A. Alkhoury, G. Lavoie, M. Civelek, A. Martinez-sanchez, P. P. Roux, T. Durcan, G. Lim

This study shows 14-3-3ζ regulates adipogenesis by modulating chromatin accessibility in adipose precursor cells, impacting gene expression and fat mass.

bioRxiv · Mar 18, 2024 · PreprintPhysiology

Synergistic action of actin binding proteins regulate actin network organization and cell shape

M. P. Serres, M. B. Smith, G. Lavoie, P. P. Roux, E. K. Paluch

The paper identifies synergistic regulation of actin networks by supervillin and myosin II, leading to stress fiber disassembly and cell rounding.

bioRxiv · Sep 15, 2023 · PreprintCell Biology

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

D. Dervovic, E. L. Y. Chen, A. Malik, S. Afiuni, J. Boucher, J. M. Berman, K. Teng, A. Ayyaz, Y. Lu, M. Narimatsu, G. Mbamalu, S. Loganathan, S. Martinez, R. Tsai, J.-B. Lee, , D. Schramek

The paper uses in vivo CRISPR screens to identify Serpinb9 and Adam2 as genes regulating immune therapy response in lung cancer, showing their roles in immune suppression and enhancement.

bioRxiv · Mar 13, 2022Cancer Biology

Proteomic analysis of the actin cortex in interphase and mitosis

N. Vadnjal, S. Nourreddine, G. Lavoie, M. Serres, P. P. Roux, E. K. Paluch

The paper compares the proteomic composition of the actin cortex in interphase and mitosis to identify regulators of cortical tension during mitotic cell rounding.

bioRxiv · Feb 16, 2022Cell Biology

Plakoglobin regulates adipocyte differentiation independently of the Wnt/β-catenin signalling pathway

F. Abou Azar, Y. Mugabo, S. Yuen, S. Del Veliz, G. Lavoie, P. P. Roux, G. E. Lim

This study identifies plakoglobin as a novel regulator of adipogenesis, independent of the Wnt/β-catenin pathway, using the 14-3-3ζ interactome in mouse and human cells.

bioRxiv · Feb 3, 2022 · PreprintBiochemistry

Genetic Landscape of Electron Transport Chain Complex I Dependency in Acute Myeloid Leukemia

I. Baccelli, Y. Gareau, B. Lehnertz, S. Gingras, J.-F. Spinella, A. Beautrait, S. Corneau, N. Mayotte, I. Boivin, S. Girard, T. MacRae, M. Frechette, K. Leveille, J. Krosl, C. Thiollier, , G. Sauvageau

The paper identifies Mubritinib as an ETC1 inhibitor effective against chemotherapy-resistant AML subtypes with OXPHOS hyperactivity and specific mutations.

bioRxiv · Jan 15, 2019 · PreprintCancer Biology