S. Martinez

SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis

This study identifies novel SETD8 inhibitors and shows their toxicity correlates with ribosome biogenesis regulators, suggesting a biomarker for targeted cancer therapy.

Mixtures of phthalates disrupt expression of genes related to lipid metabolism and peroxisome proliferator-activated receptor signaling in mouse granulosa cells

This study shows that phthalate mixtures alter gene expression in mouse granulosa cells, affecting lipid metabolism and PPAR signaling.

The nuclei of human adult stem cells can move within the cell and generate cellular protrusions to contact other cells

This study shows that human bone marrow-derived mesenchymal stem cells develop nuclei that can move within the cell and form protrusions to contact neighboring cells during neural-like differentiation.

A Re-evaluation of phylogenomic data reveals that current understanding in wheat blast population biology and epidemiology is obfuscated by oversights in population sampling

The paper re-analyzes phylogenomic data to show that previous conclusions about wheat blast population biology and epidemiology are based on incomplete sampling of grass-infecting populations.

Assessment of Storm Impact on Coral Reef Structural Complexity

This study assesses the impact of a storm on coral reef structural complexity using 3D imaging and geometrical metrics, finding that reefs recovered in two years with structural resilience.

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

The paper uses in vivo CRISPR screens to identify Serpinb9 and Adam2 as genes regulating immune therapy response in lung cancer, showing their roles in immune suppression and enhancement.

In vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer

This study uses in vivo CRISPR screens to identify USP15 and SCAF1 as novel tumor suppressors in pancreatic cancer, with potential therapeutic implications.

Recombination of standing variation in a multi-hybrid swarm drove adaptive radiation in a fungal pathogen and gave rise to two pandemic plant diseases

The paper shows that recombination of standing variation in a fungal hybrid swarm led to rapid adaptive radiation in Pyricularia oryzae, causing two new plant diseases.

Microbial community structure in rice, crops, and pastures rotation systems with different intensification levels in the temperate region of Uruguay

The paper examines microbial community structure in rice and crop rotation systems with varying intensification levels in Uruguay, finding that bacterial communities are influenced by rice rotation frequency while fungal communities are more affected by preceding crops.

A drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent local relapse and treat established brain metastasis

The paper introduces a drug-screening platform using organotypic cultures to identify effective treatments for brain metastasis, finding a potent HSP90 inhibitor that works against mouse and human metastases.

Status of the pillar coral Dendrogyra cylindrus in Los Roques National Park, Southern Caribbean

The study assesses the status of pillar coral Dendrogyra cylindrus in Los Roques National Park, finding high abundance and low disease/bleaching, but highlighting the need for MPA zoning revision to ensure conservation.

Effect of different derivatization protocols on the calculation of trophic position using amino acids compound-specific stable isotopes

The paper evaluates derivatization protocols for AA-CSIA and highlights the need for method-specific constants to improve trophic position calculations across studies.

Polyhydroxyalkanoate granule accumulation makes optical density measurement an unreliable method for bacterial growth assessment in Burkholderia thailandensis

This study shows that optical density measurements are unreliable for assessing bacterial growth in Burkholderia thailandensis due to PHA granule accumulation affecting light scattering.

Impact of within-tree organ distances on floral induction and fruit growth in apple tree: implication of carbon and gibberellin organ contents

The paper investigates how organ distances affect floral induction and fruit growth in apple trees by analyzing carbohydrate and gibberellin contents, finding short-distance effects on induction and long-distance effects on growth.