Fc-engineered antibodies leverage neutrophils to drive control of Mycobacterium tuberculosis
E. B. Irvine, J. M. Peters, R. Lu, P. S. Grace, J. Sixsmith, A. Wallace, M. Schneider, S. Shin, W. Karpinski, J. C. Hsiao, E. van Woudenbergh, A. Casadevall, B. D. Bryson, L. Cavacini, G. Alter, S. M. Fortune
This study uses Fc-engineered antibodies to enhance Mtb control by leveraging neutrophils, showing restrictive Fc variants improve neutrophil survival and antimicrobial activity in a human whole blood model.
bioRxiv · May 1, 2022 · PreprintImmunology