Author

E. B. Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Organism:rat· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

G. Alter· 3 shared J. L. Flynn· 3 shared M. Roederer· 3 shared P. A. Darrah· 3 shared S. M. Fortune· 3 shared B. D. Bryson· 2 shared J. M. Peters· 2 shared R. A. Seder· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersImmunology

G. Alter

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Author profile →

5 papers

Recent·Most cited

Deep learning-guided selection of antibody therapies with enhanced resistance to current and prospective SARS-CoV-2 Omicron variants

L. Frei, B. Gao, J. Han, J. M. Taft, E. B. Irvine, C. R. Weber, R. Kumar, B. Eisinger, S. T. Reddy

This study uses deep learning to identify antibodies resistant to SARS-CoV-2 Omicron variants by predicting their binding and escape from mutations.

bioRxiv · Oct 9, 2023 · PreprintImmunology

Humoral correlates of protection against Mycobacterium tuberculosis following intravenous Bacille Calmette-Guerin vaccination in rhesus macaques

E. B. Irvine, P. A. Darrah, S. Wang, C. Wang, R. McNamara, M. Roederer, R. A. Seder, D. A. Lauffenburger, J. L. Flynn, S. M. Fortune, G. Alter

This study identifies humoral immune responses as correlates of protection against Mtb following IV BCG vaccination in rhesus macaques.

bioRxiv · Jul 31, 2023 · PreprintImmunology

Protective intravenous BCG vaccination induces enhanced immune signaling in the airways

J. M. Peters, E. B. Irvine, J. M. Rosenberg, M. H. Wadsworth, T. K. Hughes, M. Sutton, S. K. Nyquist, J. D. Bromley, R. Mondal, M. Roederer, R. Seder, P. A. Darrah, J. L. Flynn, A. K. Shalek, S. M. Fortune, B. D. Bryson

This study shows that high-dose IV BCG vaccination in rhesus macaques enhances airway immune signaling and cellular responses, improving protection against Mtb.

bioRxiv · Jul 16, 2023 · PreprintImmunology

Fc-engineered antibodies leverage neutrophils to drive control of Mycobacterium tuberculosis

E. B. Irvine, J. M. Peters, R. Lu, P. S. Grace, J. Sixsmith, A. Wallace, M. Schneider, S. Shin, W. Karpinski, J. C. Hsiao, E. van Woudenbergh, A. Casadevall, B. D. Bryson, L. Cavacini, G. Alter, S. M. Fortune

This study uses Fc-engineered antibodies to enhance Mtb control by leveraging neutrophils, showing restrictive Fc variants improve neutrophil survival and antimicrobial activity in a human whole blood model.

bioRxiv · May 1, 2022 · PreprintImmunology

Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques

E. B. Irvine, A. O'Neil, P. A. Darrah, S. Shin, A. Choudhary, W. Li, W. Honnen, S. Mehra, D. Kaushal, H. P. Gideon, J. L. Flynn, M. Roederer, R. A. Seder, A. Pinter, S. Fortune, G. Alter

This study shows that IV BCG vaccination in macaques induces strong IgM responses associated with reduced Mtb bacterial burden and protection.

Nature Immunology · Nov 22, 2021Peer-reviewedImmunology