Author

P. Upadhyayula

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

P. Canoll· 2 shared A. Dovas· 1 shared A. Mahajan· 1 shared A. Mela· 1 shared A. Quinones-Hinojosa· 1 shared E. F. Spinazzi· 1 shared F. G. Garcia· 1 shared H. M. Levitin· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

P. Canoll

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Author profile →

2 papers

Recent·Most cited

EZH2 inhibition sensitizes IDH1R132H mutant gliomas to histone deacetylase inhibitor.

L. Sprinzen, F. G. Garcia, A. Mela, L. Lei, P. Upadhyayula, A. Mahajan, N. Humala, L. Manier, R. M. Caprioli, A. Quinones-Hinojosa, P. Casaccia, P. Canoll

This study shows that EZH2 inhibition synergizes with HDAC inhibitors to kill IDH1R132H mutant glioma cells by reducing H3K27me3 and increasing H3K27ac.

bioRxiv · Jul 31, 2023Cancer Biology

Deconvolution of Cell Type-Specific Drug Responses in Human Tumor Tissue with Single-Cell RNA-seq

W. Zhao, A. Dovas, E. F. Spinazzi, H. M. Levitin, P. Upadhyayula, T. Sudhakar, T. Marie, M. L. Otten, M. Sisti, J. N. Bruce, P. Canoll, P. A. Sims

This study uses single-cell RNA-seq to analyze cell type-specific drug responses in human tumor tissues, revealing personalized therapeutic strategies for solid tumors.

bioRxiv · Apr 22, 2020Cancer Biology