Author

N. Humala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Mahajan· 3 shared P. Canoll· 3 shared A. Dovas· 2 shared A. Mela· 2 shared J. Furnari· 2 shared J. N. Bruce· 2 shared M. G. Argenziano· 2 shared P. A. Sims· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

A. Mahajan

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

EZH2 inhibition sensitizes IDH1R132H mutant gliomas to histone deacetylase inhibitor.

L. Sprinzen, F. G. Garcia, A. Mela, L. Lei, P. Upadhyayula, A. Mahajan, N. Humala, L. Manier, R. M. Caprioli, A. Quinones-Hinojosa, P. Casaccia, P. Canoll

This study shows that EZH2 inhibition synergizes with HDAC inhibitors to kill IDH1R132H mutant glioma cells by reducing H3K27me3 and increasing H3K27ac.

bioRxiv · Jul 31, 2023Cancer Biology

A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma

M. A. Banu, A. Dovas, M. G. Argenziano, W. Zhao, H. Cuervo, D. M. Higgins, C. P. Sperring, B. Pereira, L. F. Ye, A. Mahajan, N. Humala, J. L. Furnari, P. S. Upadhyayula, F. Zandkarimi, T. T. Nguyen, , P. D. Canoll

The paper identifies a metabolic vulnerability in specific glioma cell states that can be targeted with GPX4 inhibitors to induce ferroptosis.

bioRxiv · Feb 22, 2023Cancer Biology

Single-Cell Analysis of 5-ALA Intraoperative Labeling Specificity for Glioblastoma

Z. Liu, A. Mela, J. Furnari, M. G. Argenziano, C. Kotidis, C. Sperring, N. Humala, J. N. Bruce, P. Canoll, P. A. Sims

This study shows 5-ALA labeling is not specific to transformed glioma cells but can label untransformed cells directly or via PpIX from surrounding tumor cells.

bioRxiv · Dec 17, 2022 · PreprintCancer Biology

Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic andtargetable tissue states

O. Al-Dalahmah, M. Argenziano, A. Kannan, A. Mahajan, J. Furnari, F. Paryani, D. Boyett, A. Save, N. Humala, F. Khan, J. Li, H. Lu, Y. Sun, J. Tuddenham, a. r. goldberg, , P. Canoll

The paper identifies three tissue states in glioblastoma microenvironments using snRNAseq and spatial transcriptomics, linking them to metabolic pathways and clinical outcomes.

bioRxiv · Jul 6, 2021Pathology