P. A. Sims

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age

The paper profiles immune cell RNA and protein expression across tissues and age to identify tissue-specific and age-related immune signatures.

Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma

This study uses lineage tracing and scRNA-seq to analyze drug resistance in glioblastoma cells treated with KIF11 inhibitor ispinesib, finding resistance-associated phenotypic changes and potential drug combinations.

A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma

The paper identifies a metabolic vulnerability in specific glioma cell states that can be targeted with GPX4 inhibitors to induce ferroptosis.

Single-Cell Analysis of 5-ALA Intraoperative Labeling Specificity for Glioblastoma

This study shows 5-ALA labeling is not specific to transformed glioma cells but can label untransformed cells directly or via PpIX from surrounding tumor cells.

The functional and phenotypic diversity of single T-cell infiltrates in human colorectal cancer as correlated with clinical outcome

The paper analyzes T-cell infiltration in colorectal cancer, identifying prognostic and non-prognostic T cell subtypes and their clinical implications.

Elongation Inhibitors do not Prevent the Release of Puromycylated Nascent Polypeptide Chains from Ribosomes

This study shows that elongation inhibitors do not prevent the release of puromycylated nascent polypeptides from ribosomes, challenging the use of anti-puromycin staining to determine translation sites.

Deconvolution of Cell Type-Specific Drug Responses in Human Tumor Tissue with Single-Cell RNA-seq

This study uses single-cell RNA-seq to analyze cell type-specific drug responses in human tumor tissues, revealing personalized therapeutic strategies for solid tumors.

The Harsh Microenvironment in Early Breast Cancer Selects for a Warburg Phenotype

The paper investigates how harsh microenvironments in early breast cancer select for a Warburg phenotype through metabolic and transcriptomic changes.

A single-cell reference map for human blood and tissue T cell activation reveals functional states in health and disease

Single-Cell Transcriptome Analysis of Lineage Diversity and Microenvironment in High-Grade Glioma

This study uses single-cell RNA-Seq to analyze lineage diversity and microenvironment in high-grade gliomas, finding links between cellular identity, proliferation, and population structure.