Author

A. Mahajan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 6 Biophysics· 2 Biochemistry· 1 Microbiology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 7 Approach:experimental assay· 6 Organism:mouse· 5 Approach:statistical model· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3

Frequent Co-Authors

N. Humala· 3 shared A. Dovas· 2 shared A. M. Sonabend· 2 shared A. Mela· 2 shared B. Gyorffy· 2 shared D. Saintillan· 2 shared E. Gonzalez-Buendia· 2 shared L. Chen· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

N. Humala

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

EZH2 inhibition sensitizes IDH1R132H mutant gliomas to histone deacetylase inhibitor.

L. Sprinzen, F. G. Garcia, A. Mela, L. Lei, P. Upadhyayula, A. Mahajan, N. Humala, L. Manier, R. M. Caprioli, A. Quinones-Hinojosa, P. Casaccia, P. Canoll

This study shows that EZH2 inhibition synergizes with HDAC inhibitors to kill IDH1R132H mutant glioma cells by reducing H3K27me3 and increasing H3K27ac.

bioRxiv · Jul 31, 2023Cancer Biology

A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma

M. A. Banu, A. Dovas, M. G. Argenziano, W. Zhao, H. Cuervo, D. M. Higgins, C. P. Sperring, B. Pereira, L. F. Ye, A. Mahajan, N. Humala, J. L. Furnari, P. S. Upadhyayula, F. Zandkarimi, T. T. Nguyen, , P. D. Canoll

The paper identifies a metabolic vulnerability in specific glioma cell states that can be targeted with GPX4 inhibitors to induce ferroptosis.

bioRxiv · Feb 22, 2023Cancer Biology

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

K. K. Mattis, N. A. J. Krentz, C. Metzendorf, F. Abaitua, A. F. Spigelman, H. Sun, A. K. Rottner, A. Bautista, E. Mazzaferro, M. Perez-Alcantara, J. E. Manning Fox, J. M. Torres, A. Weslowska-Andersen, G. Z. Yu, A. Mahajan, , A. L. Gloyn

This study shows that loss of RREB1 in beta cells reduces insulin content and affects gene expression, linking RREB1 to diabetes risk through its role in beta cell function and development.

bioRxiv · Jun 4, 2022Physiology

A chemomechanical model of sperm locomotion reveals two modes of swimming

C. Li, B. Chakrabarti, P. Castilla, A. Mahajan, D. Saintillan

This study presents a chemomechanical model of sperm swimming that identifies two distinct modes of locomotion with different waveforms and velocity patterns based on dynein activity.

bioRxiv · Apr 10, 2022Biophysics

Euchromatin activity enhances segregation and compaction of heterochromatin in the cell nucleus

A. Mahajan, W. Yan, A. Zidovska, D. Saintillan, M. J. Shelley

This study models nuclear chromatin organization using active Zimm chains to show how euchromatin activity drives heterochromatin segregation and compaction through hydrodynamic interactions and crosslinking.

bioRxiv · Feb 22, 2022Biophysics

Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic andtargetable tissue states

O. Al-Dalahmah, M. Argenziano, A. Kannan, A. Mahajan, J. Furnari, F. Paryani, D. Boyett, A. Save, N. Humala, F. Khan, J. Li, H. Lu, Y. Sun, J. Tuddenham, a. r. goldberg, , P. Canoll

The paper identifies three tissue states in glioblastoma microenvironments using snRNAseq and spatial transcriptomics, linking them to metabolic pathways and clinical outcomes.

bioRxiv · Jul 6, 2021Pathology

Bacterial flagella disrupt host cell membranes and interact with cytoskeletal components

E. B. Wolfson, J. Elvidge, A. Tahoun, T. Gillespie, J. Mantell, S. P. McAteer, Y. Rossez, E. Paxton, F. Lane, D. J. Shaw, A. C. Gill, J. Steveni, P. Verkade, A. Blocker, A. Mahajan, D. L. Gally

This study investigates how bacterial flagella from E. coli and Salmonella species interact with host cell membranes and cytoskeletal components, showing membrane disruption and actin polymerization effects.

bioRxiv · Feb 12, 2020 · PreprintMicrobiology

The orphan nuclear receptor estrogen-related receptor beta (ERRβ) in triple-negative breast cancer

A. I. Fernandez, X. Geng, K. Chaldekas, B. Harris, A. Duttargi, V. L. Berry, D. L. Berry, A. Mahajan, L. R. Cavalli, B. Gyorffy, M. Tan, R. B. Riggins

This study examines the association of ESRRB mRNA, copy number, and protein expression with clinicopathological features in breast cancer specimens, finding reduced ESRRB expression and distinct isoform activity in TNBC/BLBC.

bioRxiv · Aug 13, 2019Cancer Biology

CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas

J. R. Kane, J. Zhao, T. Tsujiuchi, B. Laffleur, A. Mahajan, G. Rao, A. Mela, C. Dmello, V. A. Arrieta, L. Chen, D. Y. Zhang, E. Gonzalez-Buendia, C. Lee-Chang, T. Xiao, G. Rothschild, , A. M. Sonabend

This study shows that CD8+ T-cells mediate immunoediting in murine gliomas, affecting genomic stability and immune evasion.

bioRxiv · Jul 16, 2019Cancer Biology

Interaction between DNA damage response, translation and apoptosome determines cancer susceptibility to TOP2 poisons

C. U. Awah, L. Chen, M. Bansal, A. Mahajan, J. Winter, M. Lad, L. Warnke, E. Gonzalez-Buendia, C. Park, D. Zhang, E. Feldstein, D. Yu, M. Zannikou, I. Balyasnikova, R. Martuscello, , A. M. Sonabend

The paper identifies genes involved in DNA damage response and translation that influence susceptibility to TOP2 poisons in gliomas and other cancers.

bioRxiv · Apr 25, 2019 · PreprintCancer Biology

Dextranol: A better lyoprotectant

B. J. Jones, A. Mahajan, A. Aksan

This study introduces dextranol, a modified dextran that prevents protein damage in stored samples by avoiding harmful conjugation reactions.

bioRxiv · Dec 7, 2018 · PreprintBiochemistry

Pituitary Carcinoma: The University of Texas MD Anderson Cancer Center Experience.

F. Santos-Pinheiro, M. Penas-Prado, C. Kamiya-Matsuoka, S. G. Waguespack, A. Mahajan, P. D. Brown, K. B. Shah, G. N. Fuller, I. E. McCutcheon

This study reports on 17 pituitary carcinoma patients treated at MDACC, finding that TMZ-based therapy correlates with longer disease control and higher survival rates.

bioRxiv · Sep 10, 2018Cancer Biology