C.-C. Chang

Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes

The paper shows that Spd-2 recruits Polo and Aurora A to form two distinct scaffolds, Cnn-scaffold and TACC-scaffold, which are essential for mitotic centrosome assembly in Drosophila.

FGF9, a potent mitogen, is a new ligand for integrin αvβ3, and the FGF9 mutant defective in integrin binding acts as an antagonist.

This study identifies FGF9 as a new ligand for integrin αvβ3 and shows that a mutant defective in integrin binding acts as an antagonist by suppressing FGF9 signaling.

Intratumoral Microbiome of Adenoid Cystic Carcinomas and Comparison with other Head and Neck Cancers

This study identifies distinct microbial subtypes in adenoid cystic carcinomas and links them to patient outcomes and tumor biology.

Contrasting Phyllosphere Mycobiome in two Lycopodiaceae Plant Species: Unraveling Potential HupA-Producing Fungi and Fungal Interactions

This study compares the mycobiome of two Lycopodiaceae species, identifying potential HupA-producing fungi and their interactions in Huperzia asiatica.

Temporal Transcriptome Analysis Uncovers Regulatory Modules Programming Embryo Development from Embryonic Morphogenesis to Post-Germination

The paper profiles soybean seed embryo transcriptomes across development to identify gene functions and regulatory networks involved in reserve accumulation and germination.

Structural basis of human PRPS2 filaments

This study determines the structure of hPRPS2 polymers using cryo-EM, revealing how ADP binding affects polymerization and catalytic activity.

Allosteric inhibition of PRPS is moderated by filamentous polymerization

The paper investigates two filament structures of E. coli PRPS resolved by Cryo-EM, revealing how ligand binding modulates allosteric inhibition and PRPP production.

Molecular Crowding Facilitates Bundling of IMPDH Polymers and Cytoophidium Formation

This study shows that molecular crowding promotes IMPDH polymer bundling and cytoophidium formation, with implications for protein stability and subcellular compartment function.

Neutrophil and monocyte dysfunctional effector response towards bacterial challenge in critically-ill COVID-19 patients

This study shows that severe hypercytokinemia in COVID-19 patients impairs neutrophil and monocyte function against bacterial challenges, leading to reduced microbicidal capacity and altered receptor signaling.

HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12 heterodimerization in macrophages

This study shows HLJ1 promotes IL-12 heterodimerization in macrophages, worsening sepsis severity, and suggests targeting HLJ1 could treat IL-12/IFN-γ-related diseases.

Structural basis of dynamic P5CS filaments

This study determines the structure of Drosophila P5CS filament, revealing how filamentation coordinates GK and GPR domains for catalysis.

Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment

The paper links diet-derived metabolites and mucus to fever after cytotoxic cancer treatment by showing how Akkermansia muciniphila affects colonic mucus and inflammation.

Ser/Thr phospho-regulation by PknB and Stp mediates bacterial quiescence and antibiotic persistence in Staphylococcus aureus

Blunted Fas signaling favors RIPK1-driven neutrophil necroptosis in critically ill COVID-19 patients

The paper shows that in critically ill COVID-19 patients, dysregulated Fas signaling leads to increased RIPK1-driven necroptosis in neutrophils, contributing to disease severity.

Liver Electrical Impedance Tomography for Early Identification of Fatty Infiltrate in Obesity

This study uses liver electrical impedance tomography to detect fatty infiltration in obese individuals, finding a negative correlation between EIT conductivity and MRI-measured fat fraction.

Structure-based functional study of a peptide of an ecdysozoan superfamily: reveling a common molecular architecture and receptor-interacting residues

The paper functionally and structurally analyzes a neuropeptide from the CHH superfamily, revealing a conserved molecular architecture and identifying key receptor-interacting residues.

An embryonic zebrafish model to screen disruption of gut-vascular-barriers upon exposure to ambient ultrafine particles

This study uses zebrafish embryos to show that exposure to ultrafine particles disrupts the gut-vascular barrier by modulating Notch signaling.

Selective Plane Illumination Microscopy and Computing Reveal Differential Obliteration of Retinal Vascular Plexuses

The paper uses 3-D imaging and computational analysis to show preferential obliteration of retinal secondary plexuses in hyperoxia-induced retinopathy.

Saak Transform-Based Machine Learning for Light-Sheet Imaging of Cardiac Trabeculation

This paper develops a Saak transform-based machine learning framework for efficient segmentation and quantification of cardiac trabeculation in light-sheet images after chemotherapy.