P.-Y. Ho

Challenges in quantifying functional redundancy and selection in microbial communities

The paper challenges the assumption that reduced functional variability in microbial communities indicates selection, showing that apparent functional selection can be artifacts of statistical averaging and functional bias.

Assembly of gut-derived bacterial communities follows "early-bird" resource utilization dynamics

This study shows that gut microbiota assembly follows 'early-bird' dynamics where fast-growing species dominate nutrient sources, and develops a predictive model for community composition based on nutrient inputs.

Oral Delivery of Kidney Targeting Nanotherapeutics for Polycystic Kidney Disease

This study develops an oral nanoparticle delivery system for metformin in ADPKD, showing improved kidney targeting and bioavailability compared to conventional methods.

Antibiotic effects on microbial communities are modulated by resource competition

This study shows how resource competition affects microbial community diversity in response to antibiotics, revealing non-monotonic richness changes and non-transitive/non-additive effects.

Resource competition predicts assembly of in vitro gut bacterial communities

This study develops a framework to distinguish resource competition from other interactions in gut bacterial communities, showing it explains most pairwise interactions and predicts community assembly.

In vivo augmentation of a complex gut bacterial community

The paper improves a synthetic gut microbiota community by adding strains that persist after fecal challenge and removing those that do not, resulting in a more stable model of the human gut microbiome.

Competition for fluctuating resources reproduces statistics of species abundance over time across wide-ranging microbiotas

The paper shows that resource competition models can replicate species abundance time series statistics across diverse microbiotas, suggesting resource competition drives community dynamics.

A model for the regulation of the timing of cell division by the circadian clock in the cyanobacterium Synechococcus elongatus

The paper proposes a modulated rates model to explain how the circadian clock in Synechococcus elongatus regulates cell division timing, showing it better explains environmental changes than the gating model.