Cancer-Associated Hypercalcemia Signals Through the Hindbrain to cause Anorexia
Diego Y. Grinman, Farzin M. Takyar, Pamela Dann, Marya Shanabrough, Stacey Brown, Alisson Clemenceau, Julie R. Hens, Bernardo Stutz, Lewis A. Chodosh, Wenhan Chang, Gerald I. Shulman, Tamás L. Horváth, John J. Wysolmerski
This study shows that hypercalcemia from tumor-secreted PTHrP activates hindbrain circuits linked to anorexia, and blocking hypercalcemia prevents these effects.
Journal of bone oncology · Apr 1, 2024Peer-reviewedCancer Biology