Tamás L. Horváth

AgRP Neuronal Suppression by Spontaneous Movement Encodes Exercise Reinforcement

The paper shows that spontaneous movement suppresses AgRP neuron activity, reinforcing exercise behavior in mice.

Diet context gates AgRP neuron involvement in Semaglutide-induced weight loss

The paper shows that AgRP neurons are necessary for Semaglutide-induced weight loss in female mice on standard diet but not on high-fat diet.

Cysteine depletion triggers adipose tissue thermogenesis and weight-loss.

This study shows that cysteine depletion induces adipose browning and weight loss in mice, mediated by noradrenaline signaling via β3-adrenergic receptors, without requiring UCP1.

Mitofusin 2 controls mitochondrial and synaptic dynamics of suprachiasmatic VIP neurons and related circadian rhythms including sleep

This study shows that mitofusin 2 regulates mitochondrial and synaptic dynamics in SCN VIP neurons, affecting circadian rhythms and sleep in mice.

Sympathetic neuron-derived NPY protects from obesity by sustaining the mural progenitors of thermogenic adipocytes.

This study shows that sympathetic neuron-derived NPY sustains mural progenitors of thermogenic adipocytes, protecting against obesity by maintaining thermogenic capacity.

Cancer-Associated Hypercalcemia Signals Through the Hindbrain to cause Anorexia

This study shows that hypercalcemia from tumor-secreted PTHrP activates hindbrain circuits linked to anorexia, and blocking hypercalcemia prevents these effects.

LINE-1 activation in the cerebellum drives ataxia

This study shows that activation of young LINE-1 elements in the cerebellum causes ataxia by inducing DNA damage, inflammation, and neuronal dysfunction in mice.

Ucp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior

The paper identifies Ucp2-dependent microglia-neuronal interactions that regulate ventral hippocampal circuit function and anxiety-like behavior through synapse remodeling and ROS dynamics.

Defective Autophagy in Sf1 Neurons Perturbs the Metabolic Response to Fasting and Causes Mitochondrial Dysfunction

This study shows that autophagy in Sf1 neurons of the VMH is essential for metabolic responses to fasting and mitochondrial function.