Arginine synthesis pathway and ASS1 play a critical role in mRNA translation reprogramming and ICI resistance in cutaneous melanoma
Emilie Chessel, Wassila Khatir, Ana Carolina Bastos Sant'Anna Silva, Patricia Abbe, Guillaume E. Béranger, Zheyu Ding, Thierry Passeron, Issam Ben‐Sahra, Henri Montaudié, Caroline Robert, Shensi Shen, Stéphane Rocchi, Michaël Cerezo
This study identifies arginine synthesis pathway and ASS1 as key factors in mRNA translation reprogramming and ICI resistance in cutaneous melanoma, showing that targeting ASS1 can restore sensitivity to anti-PD-1.
bioRxiv · Mar 18, 2026 · PreprintCancer Biology