Stéphane Rocchi

SNUPR enables single-cell UPR profiling and reveals the role of IRE-1 axis in predicting bortezomib resistance in multiple myeloma.

The paper identifies two compounds that target GPX4 and TXNRD1 to induce apoptosis and ferroptosis in AML cells, effectively eradicating malignant cells while sparing normal hematopoietic cells.

This study identifies arginine synthesis pathway and ASS1 as key factors in mRNA translation reprogramming and ICI resistance in cutaneous melanoma, showing that targeting ASS1 can restore sensitivity to anti-PD-1.

This study shows that combining a HDAC3 inhibitor with 5-Azacitidine enhances anti-tumor effects against DLBCL in vitro and in vivo, with reduced toxicity compared to single agents.

This study identifies MELK as a key driver of metabolic adaptation and therapy resistance in melanoma, showing that inhibiting MELK can sensitize resistant cells to immunotherapy.

The paper shows SubAB induces IFN-I in pDCs via STING activation and UPR, highlighting a novel mechanism of immune regulation.