Author

Rodrigue Rossignol

Université de BordeauxORCID 0000-0002-8983-2465Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

Nívea Dias AmoêdoiD· 2 shared Adam R. Dorfman· 1 shared Alexandre HenriquesiD· 1 shared Aline Soares Freire· 1 shared Ana Carolina Bastos Sant'Anna SilvaiD· 1 shared Ana Paula Miranda MendonçaiD· 1 shared Bernardo Ferreira BraziD· 1 shared Caroline RobertiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

Nívea Dias AmoêdoORCID

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Author profile →

3 papers

Recent·Most cited

Iron exposure reprograms redox homeostasis through mitochondrial depolarization in neuroblastoma

Ana Paula Miranda Mendonça, Stéphane Claverol, Bernardo Ferreira Braz, Aline Soares Freire, Franklin David Rumjanek, Ricardo Erthal Santelli, Caroline Tokarski, Danielle Bruno de Carvalho, Rodrigue Rossignol, Nívea Dias Amoêdo, Marcus Fernandes de Oliveira

This study shows that non-toxic iron overload in neuroblastoma cells reprograms mitochondrial and redox metabolism by increasing proton leak and reducing oxidant production.

bioRxiv · Oct 9, 2026 · PreprintBiochemistry

MELK controls tumor metabolism to promote resistance to melanoma therapy

Ana Carolina Bastos Sant'Anna Silva, Patricia Abbe, Sophie Pagnotta, Nívea Dias Amoêdo, Michael D. Torno, Fanny Bonnard, Thomas Botton, Frédéric Larbret, Cyril Ronco, Henri Montaudié, Issam Ben‐Sahra, Caroline Robert, Thierry Passeron, Rodrigue Rossignol, Michaël Cerezo, Stéphane Rocchi

This study identifies MELK as a key driver of metabolic adaptation and therapy resistance in melanoma, showing that inhibiting MELK can sensitize resistant cells to immunotherapy.

bioRxiv · Dec 31, 2025 · PreprintCancer Biology

A Mechanism Underpinning the Bioenergetic Metabolism-Regulating Function of Gold Nanocatalysts

Zixin Wang, Alexandre Henriques, Laura Rouvière, Noëlle Callizot, Lin Tan, Michael T. Hotchkin, Rodrigue Rossignol, Mark G. Mortenson, Adam R. Dorfman, Karen S. Ho, Hui Wang

This paper investigates how gold nanocrystals regulate bioenergetic metabolism by catalyzing NADH oxidation, enhancing ATP production, and improving neuronal survival under stress.

Small · Sep 28, 2023Peer-reviewedNeuroscience